Bi-layer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second ...

Terapi farmakologi lini pertama pada pasien diabetes melitus terutama tipe II obesitas dan yang memiliki fungsi ginjal normal adalah metformin. Namun, metformin dengan sistem pelepasan segera ditemukan banyak kelemahan seperti menimbulkan efek samping rendahnya kepatuhan pasien. Untuk mengatasi hal tersebut, maka dikembangkan formulasi diperpanjang (extended release). Tujuan penulisan review ar...

The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on drug release from valproic acid-sodium valproate matrix tablets prepared with w...

Abstract: Introduction: Diabetes Mellitus (DM) is one of the most prevalent and chronic illnesses associated with an abnormally high level glucose in body which hazardous to organs. Metformin Hydrochloride (HCl), a biguanide derivative used for Type 2 DM. It has relatively short plasma half-life its regular administration required maintain normal blood diabetic patients. Therefore, sustained-re...

The objective of the current study was to design an oral sustained release matrix tablet of Ramipril and to evaluate the effect of polymer on release pattern of the drug. Tablets were prepared by direct compression method using Methocel (Hydroxy Propyl Methyl Cellulose) K100MCR and Methocel (Hydroxy Propyl Methyl Cellulose) K4MCR, as matrix forming polymer. Dissolution studies were carried out ...