The WHO/ILAR core set of endpoints for rheumatoid arthritis clinical trials signifies progress in a continuing worldwide effort. This core set includes the following measures: pain, patient global assessment, physical disability, swollen joints, tender joints, acute phase reactants, and physician global assessment; in studies of one or more years' duration, radiographs of joints should be perfo...

INTRODUCTION Early rheumatoid arthritis (RA) patients may show rapid radiographic progression (RRP) despite rapid initiation of synthetic disease-modifying anti-rheumatic drugs (DMARDs). The present study aimed to develop a matrix to predict risk of RRP despite early DMARD initiation in real life settings. METHODS The ESPOIR cohort included 813 patients from the community with early arthritis...

Results 32 (64%) primarily admitted for gout with a median stay of 8 days. 6 of these admissions were due to polyarticular gout. 18 patients had gout developing during an admission for another cause. Length of stay was increased in 4 of these patients by a median of 4.5 days. Of those primarily admitted with gout, 17 had a past history of gout, of which 13 had either been on or were still takin...

A 6-year-old male patient who was suffering from a cold and a transient ischemic attack was scheduled to undergo encephalo-duro-arterio-synangiosis for treating his moyamoya disease. Acute brain edema occurred just after opening the dura mater. Head elevation, reduction of the head rotation and hyperventilation were done. The inhalational agents were discontinued and total intravenous anesthesi...

We report on the synthesis of nanocomposites with integrated ellipsoidal silica-coated hematite (SCH) spindle type nanoparticles which can act as crosslinking agents within an elastomeric matrix. Influence of the surface chemistry of the hematite, leading either to dispersed particles or crosslinked particles to the elastomer matrix, was studied via swelling, scattering and microscopy experimen...

Mitochondrial physiology is disrupted in either apoptosis or necrosis. Here, we report that a wide variety of apoptotic and necrotic stimuli induce progressive mitochondrial swelling and outer mitochondrial membrane rupture. Discontinuity of the outer mitochondrial membrane results in cytochrome c redistribution from the intermembrane space to the cytosol followed by subsequent inner mitochondr...

In pulmonary congestion dyspnoea is due not only to an increase in elastic but also in viscous work. Increased airway resistance can be reduced in most of these cases by inhalation of adrenergic or anticholinergic agents. Therefore, besides bronchial mucosal swelling induced by congestion in the bronchial vessels via bronchopulmonary anastomoses, bronchospasm can take place and lead to cardiac ...

Key points • Melkersson-Rosenthal syndrome should be suspected in cases of recurrent facial palsy associated with swelling of orofacial structures and/or a furrowed tongue. • Biopsy of suggestive lesions typically reveals noncaseating granulomas with perivascular and lymphatic inflammatory cell infiltration. • The pathophysiology involves an immunologically mediated inflammatory response. • Tre...