We describe the synthesis and biological evaluation of newly designed 2,4,6-trisubstituted symmetrical 1,3,5-triazine (TAZ) derivatives. Among the tested trisubstituted symmetrical TAZ derivatives, various C3- or CS-symmetrical alkoxy-amino-substituted TAZ derivatives showed significant antiviral activity against herpes simplex virus type 1 (HSV-1) and/or cytotoxic activity against Vero cells. ...

Two cases of symmetrical peripheral gangrene associated with intracardiac lesions are described. One had a secondary deposit from a uterine leiomyosarcoma in the wall of the right ventricle, the other had a free ball thrombus in the right atrium; there were no valvular lesions in either case. The published reports of this type of gangrene indicate that it may result from (1) va sospastic condit...

Low attenuation of the cerebral white matter occurs with oedema and demyelination. When unilateral or asymmetrical it is usually due to a tumour, granuloma or abscess. The nidus responsible for the vasogenic oedema can be demonstrated after contrast enhancement. Bilateral demyelination occurs especially with viral infections such as herpes simplex encephalitis and progressive multifocal leukoen...