Investigating aging effects on the sympathetic nervous system and ascertaining underlying central nervous system (CNS) mechanisms mediating sympathetic stimulation is clinically pertinent because of the possible interconnection of cardiovascular disease development with age-dependent sympathetic nervous changes. Because of previous evidence linking human CNS neuronal noradrenergic function and ...

We wish to comment on the article by de Champlain and Ameringen (Circ Res 31:617-628, 1972) in which they implicate the involvement of the peripheral sympathetic nervous system in the etiology of deoxycorticosterone (DOCA)-saline hypertension. In the Discussion of their article, the work of Clarke et al. (Life Sci [I] 9:1097-1108, 1970) has been misquoted. Contrary to the authors' impression, w...

Heart failure (HF) is a syndrome characterized by upregulation of the sympathetic nervous system and abnormal responsiveness of the parasympathetic nervous system. Studies in the 1980s and 1990s demonstrated that inhibition of the renin-angiotensin-aldosterone system with angiotensin-converting enzyme inhibitors improved symptoms and mortality in HF resulting from systolic dysfunction, thus pro...

Let's read! We will often find out this sentence everywhere. When still being a kid, mom used to order us to always read, so did the teacher. Some books are fully read in a week and we need the obligation to support reading. What about now? Do you still love reading? Is reading only for you who have obligation? Absolutely not! We here offer you a new book enPDFd hypertension and the sympathetic...

pain Sir: We read with interest the recent review by Dr Kidd and colleagues on the role of the sympathetic nervous system in chronic joint pain and inflammation.' The authors suggest, on the one hand, a continued influence of the sympathetic nervous system on the inflammatory synovium while, on the other hand, they postulate that nerve fibres are destroyed in the synovial membrane in chronic rh...

Disturbance of this system occurs because the nerves involved run along the spinal cord in the "sympathetic and parasympathetic chains" (thoraco-lumbar and cranio-sacral respectively) and also because of the effects of unrelieved pain on stress hormones. Bowsher's paper ( [1] ) on central pain describes how most patients with central pain develop "autonomic instability", by...

For those who have comfortably accepted the mechanistic link between sympathetic nervous system activation and poor outcome in heart failure, the study by Brede et al1 in this issue of Circulation is a welcome confirmation. The authors appear to have demonstrated in a murine model that absence of sympathoinhibitory 2 adrenoreceptors is associated with overactive catecholamine release, aggressiv...