Amyloid involvement of the tongue is almost always secondary to systemic amyloidosis. Isolated amyloidosis of the tongue is relatively rare and it accounts for less than 9% of all types of amyloidosis. We are presenting a case of a 54-year-old male patient who complained of an enlarged tongue and bilateral multiple swellings on the lateral borders of the tongue, which had been there since one y...

Amyloidosis is a rare disorder caused by deposition of amyloid fibrils in various tissues causing structural and functional defects. Depending upon organs involved, it may be categorized as localized or systemic. Systemic amyloidosis involves multiple organs where some organs are affected more commonly than others. Diagnosis is often challenging as in a 76-yearsold female described here who pre...

Amyloidosis is a rare disease characterised by the deposition of insoluble extracellular fibrillar proteins in various tissues of the body. The pattern of manifestation is organ dependent and also on whether the disease is localised or systemic, primary or secondary. Primary systemic amyloidosis is a disease of adulthood. In reported cases, the mean patient age of onset is 65 years. We report a...

INTRODUCTION Localized amyloidosis in the head and neck is a rare and generally benign condition. In the oral cavity, amyloidosis usually involves the tongue or buccal mucosa. We present the second case of oral amyloidosis arising in the gingiva ever reported, to the best of our knowledge. CASE PRESENTATION A 73-year-old White Spanish man presented a persistent nodular mass involving his uppe...

Systemic amyloidoses are a wide group of diseases with different courses, treatments and prognoses. Unequivocal typing of amyloid deposits is important for correct diagnosis and appropriate treatment. At present, the most effective therapeutic approach is based on eliminating the supply of amyloidogenic precursor. New effective therapies will stem from our improved knowledge of the molecular me...

Amyloidosis is a group of rare progressive diseases that occur as result abnormal protein folding and aggregation. Systemic amyloidosis serious disease with high mortality, prompt diagnosis key to improving prognosis. Conversely, localised does not reduce life expectancy can often be treated simple surgical excision. Amyloid deposits found in the oral cavity, usually context systemic amyloidosi...

Amyloidosis is a broad and complex class of diseases that comprises several etiologies, many manifestations, and a diversity of outcomes. We discuss a patient with primary systemic amyloidosis associated with multiple myeloma that illustrates many of the typical and atypical features of the disease process. Despite more in-depth assessment and accurate classification, survival for patients with...

The median survival in primary systemic (AL) amyloidosis is less than 18 months. No published series of patients with AL amyloidosis have reported survival of more than 10 years. The records of all Mayo Clinic patients with a diagnosis of AL amyloidosis between January 1, 1966 and March 1, 1987 were reviewed. Patients with secondary amyloidosis, familial amyloidosis, senile systemic amyloidosis...

Amyloidosis is a rare, mysterious and serious disorder. The extracellular deposition of seemingly homogenous and amorphous material actually represents the expression of very diverse pathologies. All amyloid fibrils share apple green birefringence under polarized light with Congo-red staining, and are arranged in beta-pleated structure on electron microscopy. More than 21 proteins have been ide...

BACKGROUND Amyloidosis cutis dyschromica is a rarely documented variant of cutaneous amyloidosis. To date, only 26 cases have been reported. OBJECTIVE The purpose of this study was to improve the clinical and histopathological data for this variant of amyloidosis and to highlight the immunohistochemical features of the disease. The published cases were also reviewed. METHODS We performed a ...