BACKGROUND Nonmelanoma skin cancers are the most frequent malignancies in organ transplant patients. Patients who develop multiple new skin cancers may benefit from retinoid chemoprevention. OBJECTIVE The objective of this study was to advise on the use of retinoids in organ transplant recipients. METHODS A summary was performed of the existing literature regarding experience with retinoid ...

PURPOSE The potential of microRNAs (miRNAs) as novel tumor markers has been the focus of recent scrutiny because of their tissue specificity, stability, and association with clinicopathological parameters. Data have emerged documenting altered systemic miRNA expression across a spectrum of cancers; however, it remains uncertain as to whether circulating miRNAs are tumor specific. Our aim was to...

Background and objectives: Advanced rectal cancers require local and systemic control. Chemo radiotherapy (CRT) is adequate to achieve adequate local control. Systemic control, however, is a dominant obstacle remained in debates. We compared oncology outcome in both arms in patients with advanced rectal cancers in order to identify high-risk group of distant metastasis. Methods: Data for 723 pa...

Worldwide, hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death. In the U.S., 18,510 new cancers of the liver and intrahepatic bile duct are expected in 2006, with an estimated 16,200 deaths. The incidence rates for HCC in the U.S. continued to rise steadily through 1998 and doubled during the period 1975-1995. Unresectable or me...

Three rat sarcoma (RAS) gene isoforms, KRAS, NRAS, and HRAS, constitute the most mutated family of small GTPases in cancer. While development targeted immunotherapies has led to a substantial improvement overall survival patients with non-KRAS-mutant cancer, RAS-mutant cancers have an poorer prognosis owing high aggressiveness tumors. KRAS mutations are strongly implicated lung, pancreatic, col...

The availability of new systemic therapies associated with better outcomes and survival for GU tumors is a major obstacle most LMIC. Strategies to improve access are necessary depend not only on drug availability, but from public health care system organization, discussion priorities as well strategies decrease cost by rational treatment decision individualize use in limited resource countries....

background: systemic candidiasis is a major complication in neutropenic cancer patients undergoing treatment. most systemic fungal infections emerge from endogenous microflora so the aim of the present study was to identify candida species isolated from the different regions of body   in neutropenic patients in compare with the control group. methods: a total of 309 neutropenic cancer patients ...

Abstract Debulking surgery, also called cytoreductive is a resection of the tumor as much possible and an intended incomplete for unresectable malignant tumors. Since most important principle in surgical oncology complete R0 resection, debulking surgery goes against basic obscures concept operability. However, has been advocated various types advanced tumors, including gynecological cancers, ur...

In the clinical state of oligometastases or oligorecurrence, a transitional state between localized and widespread systemic disease, local control of the disease may yield improved systemic control. Radiotherapy may be a good means for controlling oligometastatic tumors, particularly in very old patients for whom surgery may be infeasible. A combination of systemic therapy and local therapy is ...