Background : Acute myelogenous leukemia is a cancer that affects myeloid cells. Several complications occur due to acute myelogenous leukemia of which is granulocytic sarcoma. This case report discusses the analysis of skin abnormalities in an acute myelogenous leukemia patient. Case description : Skin examination and fine needle aspiration of the nodules in comparison with previous bone marrow...

Lymphomatoid papulosis (LyP) is a benign papulonodular skin eruption with histologic features of malignant lymphoma. A new variant of LyP which was termed "type E" was recently described with similar clinical and histological features to angiocentric and angiodestructive T-cell lymphoma. LyP type E is characterized with recurrent papulonodular lesions which rapidly turn into hemorrhagic necroti...

Cutaneous T-cell lymphoma (CTCL) constitutes a malignant proliferative disease involving mostly CD4(+) T cells arising in the skin. Because of the lack of curative treatment options, interferons (IFN) have been introduced into the therapy of CTCL. Although effective even in advanced disease, response rates were about 50% and the duration of response was short. To improve the results of interfer...

Starting at the end of 90’s, and derived from PUVA therapy, arose the concept of modulation of inappropriate immune conflicts by direct action of UVA on immunocompetent cells (lymphocytes, antigen processing cells). After the inactivation of T-cells in vitro and ex vivo, was demonstrated, the development step-by-step aimed to process large amounts of the so-called peripheral mononuclear cells. ...

Even before the recent development of biological agents, a long list of effective treatments has been available for patients with psoriasis. Topical therapies such as corticosteroids, vitamin D analogues, and retinoids are used for localised disease. Phototherapy including broadband ultraviolet B (UVB), narrowband UVB, PUVA, and climatotherapy are effective for more extensive disease. Systemic ...

CONTEXT Each year tens of thousands of patients in the United States are treated with UV-B radiation or psoralen plus UV-A radiation (PUVA) for a variety of skin disorders. Although PUVA is generally considered more effective, it is also more toxic and more expensive. The degree of consensus among experts in prescribing these alternative treatments has not been quantified. OBJECTIVES To quant...

A bullous eruption in a patient with psoriasis was first described by Bloom in 1929 (as cited by Weber) (1). Since then there have been several reports of bullous pemphigoid occurring during the treatment of psoriasis, especially after ultraviolet (UV) B exposure. Comorbidity of these two diseases without treatment has also been reported (2,3). Psoriasis is one of the most common chronic inflam...

445 Letters to the Editor Sir, Extracorporeal photopheresis (ECP) is described as effective and safe in the treatment of erythrodermic cu-taneous T-cell lymphoma (CTCL) (1). It is thought that ECP acts mainly through the induction of apoptotic cell death in leukocytes; this apoptotic cell death may cause subclinical immunosuppression. Actinically derived squamous cell carcinoma (SCC) are usuall...

Case Report A 53-year-old male anaesthetist with a widespread, histologically proven psoriasis vulgaris was treated with oral photochemotherapy (PUVA) after failure of multiple intensive topical treatments and poor response to UVA-UVB phototherapy. PUVA was begun according to our standard protocol: 2 h after oral administration of 5-MOP 100 mg (Geralen , 1.2 mg/kg body weight), the patient was ...

Case Report A 53-year-old male anaesthetist with a widespread, histologically proven psoriasis vulgaris was treated with oral photochemotherapy (PUVA) after failure of multiple intensive topical treatments and poor response to UVA-UVB phototherapy. PUVA was begun according to our standard protocol: 2 h after oral administration of 5-MOP 100 mg (Geralen , 1.2 mg/kg body weight), the patient was ...