Oncoprotein E2a/Pbx1 is produced by the t(1;19) chromosomal translocation of human pre-B acute lymphoblastic leukemia. E2a/Pbx1 blocks differentiation of primary myeloid progenitors but, paradoxically, induces apoptosis in established pre-B-cell lines, and no transforming function of E2a/Pbx1 has been reported in cultured lymphoid progenitors. Here, we demonstrate that E2a/Pbx1 induces immortal...

This issue of Cancer Control focuses on the clinicopathologic features of chronic T-cell leukemia/ lymphoma. Chronic leukemia of T-cell origin was first identified by Brouet and colleagues in 1975. Several classification systems for T-cell lymphoid malignancies have been proposed since then. The French-American-British (FAB) Cooperative Group’s proposal for classification designated four subgro...

Abstract Introduction/Objective Myeloid/lymphoid neoplasms with rearrangement of FGFR1 are uncommon and heterogeneous group hematological malignancies that may present as myeloproliferative neoplasm, acute myeloid leukemia, T or B lymphoblastic lymphoma/leukemia, mixed phenotypic leukemia. Patients can lymphadenopathy, mediastinal mass, systemic symptoms. Eosinophilia is common in peripheral bl...

Adult T cell leukemia-lymphoma is a rare disease with a high mortality rate, and is challenging for the clinician. Early allogeneic stem cell transplant can confer durable remission. As novel therapeutic agents become available to treat T cell malignancies, it is increasingly important that medical oncologists, hematologists, and hematopathologists recognize and accurately diagnose adult T cell...