Abstract BACKGROUND: Previously, we reported a case of familial medulloblastoma without hereditary tumor syndrome. Through analysis the whole genome sequencing family members, found common germline WTX (c.1863C>T, p.Gly435Asp) mutation in this family: cytosine (C) at position 63411863 on X chromosome was replaced by thymine (T), and corresponding amino acid glycine Gly (G) 435, which con...