ba ckground: liver cancer is one of the deadly cancers with high prevalence in the east asia. likewise most of diseases, herbs and herbal medicine could be an easy and cost effective tool in prevention and possible cancer treatment. the present study investigated the ability of orthosiphon stamineus benth decoction to protect liver against hepatocellular carcinoma in carcinogenesis-induced anim...

objective(s): this paper aims to investigate synergistic inhibition of polysaccharide from sepia esculenta ink (sip), a newly isolated marine polysaccharide in our laboratory, on breast cancer mda-mb-231 cells exposed to cisplatin. materials and methods: cell viability of mda-mb-231 cells was determined by cck 8 assay. median-effect concentration was analyzed using chou-talalay method that was ...

In this study we investigated whether interleukin 2 (IL-2) acts on B cell proliferation and whether activated B cells express IL-2 receptors. First, the functional activity of immunoaffinity-purified or recombinant human IL-2 was studied in a B blast assay using positively selected murine surface Ig-positive cells that had been activated by lipopolysaccharide (LPS) plus anti-Ig antibodies (anti...

background: while articular chondrocytes are among those appropriate candidates for cartilage regeneration, the cell dedifferentiation during monolayer culture has limited their application. several investigations have indicated the usefulness of alginate, but the topic of proliferation and differentiation of chondrocytes in alginate culture has still remained controversial. methods: rat articu...

the anti-cancer activity of metal ions in the lanthanide group is being considered recently. it has been reported that cerium salts might stimulate the metabolism and therefore, produce anti-cancer effects. however, little is known about the effects of protein-cerium complex in controlling cancer cell growth. the aim of the present study was to elucidate the possible pathways for the cytotoxic ...

In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...

objective(s): lipocalin2 (lcn2) gene is highly expressed in response to various types of cellular stresses. the precise role of lcn2 has not been fully understood yet. however, it plays a key role in controlling vital cellular processes such as proliferation, apoptosis and metabolism. recently it was shown that lcn2 decreases senescence and increases proliferation of mesenchymal stem cells (msc...

OBJECTIVE To investigate the prevalence of beta-cell autoantigen-reactive peripheral T-cells in type 1 diabetes, we developed an immunoglobulin-free enzyme-linked immunospot (ELISPOT) assay and assessed its usefulness for diagnosing this disease. RESEARCH DESIGN AND METHODS Cellular immune responses to beta -cell autoantigens were studied both by immunoglobulin-free proliferation assays and E...