Coiled-coil tropomyosin binds to consecutive actin-subunits along actin-containing thin filaments. Tropomyosin molecules then polymerize head-to-tail to form cables that wrap helically around the filaments. Little is known about the assembly process that leads to continuous, gap-free tropomyosin cable formation. We propose that tropomyosin molecules diffuse over the actin-filament surface to co...

We used first-principle simulation methods to generate amorphous TiO2 (a-TiO2) models and obtained chemically-ordered amorphous networks. We analyzed the structural and the electronic properties of the resulting computationally generated structures. We propose that two peaks found in the Ti-Ti pair correlation correspond to the edge-sharing and the corner-sharing Ti-Ti pairs. Resulting coordina...

Assessing the probability of occurrence of extreme events is a crucial issue in various fields like finance, insurance, telecommunication or environmental sciences. In a multivariate framework, the tail dependence is characterized by the so-called stable tail dependence function (STDF). Learning this structure is the keystone of multivariate extremes. Although extensive studies have proved cons...

Ca(2+)/calmodulin-dependent protein kinase, type II (CaMK-II) is an enzyme encoded by four genes (alpha, beta, gamma and delta) and traditionally associated with synaptic function in the adult central nervous system, but also believed to play a role during neuronal development. P19 mouse embryonic cells are a model system for neurogenesis and primarily express isozymes of delta CaMK-II. It is n...

We investigate the influence of intra-chain and inter-chain interactions on the sub-gap density of states in a conjugated polymer using a combination of atomistic molecular dynamics simulation of polymer film structure and tight-binding calculation of electronic energy levels. For disordered assemblies of poly-3-hexylthiophene we find that the tail of the density of hole states is approximately...

The standard picture of CV secular evolution predicts a spike in the CV distribution near the observed short–period cutoff P0 ≃ 78 min, which is not observed. We show that an intrinsic spread in minimum (‘bounce’) periods Pb resulting from a genuine difference in some parameter controlling the evolution can remove the spike without smearing the sharpness of the cutoff. The most probable second ...

Rat tail tendon collagen fibrils disaggregated in the mild experimental conditions to sub-fibrillar structures. The smallest, most frequent (protofibrils) were of fairly constant thickness, 12-15 nm. They often arose from larger subfibrils ( > 25 nm) that were nevertheless much smaller than the parent fibril. The protofibrils retained a faint banding pattern. They were oriented helically. The 2...

The biogenesis of connexins and their assembly into functional gap junction hemichannels (connexons) was studied with the use of a cell-free transcription/translation system. Velocity sedimentation on sucrose gradients showed that a small proportion of connexin (Cx) 26 and Cx32 that were co-translationally translocated into microsomes were oligomers of Cx26 and Cx32. Chemical cross-linking stud...

The purpose of this study was to determine the taxonomic status of an unidentified enigmatic macaque seen by scientists since the late 1990s in Arunachal Pradesh, India. We surveyed 49 troops of enigmatic macaques in four districts of Arunachal Pradesh. The population studied is from the macaque sinica-group as defined by the reproductive organs. The main species-separating trait in the sinica-...

eristalis tenax , belonging to order diptera, family syrphidae seldomly causes in­tes­tinal myiasis. intestinal myiasis caused by e. tenax larvae is a rare manifesta­tion found in both humans and other vertebrate animals. we report a 22-year-old woman presented with this myiasis. the larva in her stool sample was identified as e. tenax related to its typical morphology and authentic clues. lack...