Uridylation of RNA species represents an emerging theme in post-transcriptional gene regulation. In the microRNA pathway, such modifications regulate small RNA biogenesis and stability in plants, worms, and mammals. Here, we report Tailor, an uridylyltransferase that is required for the majority of 3' end modifications of microRNAs in Drosophila and predominantly targets precursor hairpins. Uri...

Data cleaning is a vital process that ensures the quality of data stored in real-world databases. Data cleaning problems are frequently encountered in many research areas, such as knowledge discovery in databases, data warehousing, system integration and e-services. The process of identifying the record pairs that represent the same entity (duplicate records), commonly known as record linkage, ...

The translation apparatus is the cell’s factory for protein synthesis, stitching together amino acid substrates into sequence-controlled polypeptides (proteins) from a defined template. With protein elongation rates of up to 20 amino acids per second and an accuracy of 99.99% (ref. 1), prokaryotic translation is faster and more accurate than many enzymatic conversions that require only a single...

This work explores the potential of analyzing individual objects to improve their preventive conservation. Previously, environmental recommendations have been based on an average or worst response material groups. Cultural heritage are extremely variable and within a group such as archaeological iron very wide range responses shown. Characterizing single object’s allows its environment be tailo...

In order for intelligent systems to be applicable in a wide range of situations, end users must be able to modify their task descriptions. We introduce Tailor, a system that allows users to modify task information through instruction. In this approach, the user enters a short sentence to describe the desired change. The system maps the sentence into valid, plausible modifications and checks for...

in the past, disease diagnosis was based on symptoms that might be indicative of several diseases. nowadays, diagnosis of some diseases has become more accurate because we are able to test for genes known to be associated with the disease. this method not only clearly identifies the presence of a particular disease; it can also precisely determine the subtype of the disease. throughout history,...

In the past, disease diagnosis was based on symptoms that might be indicative of several diseases. Nowadays, diagnosis of some diseases has become more accurate because we are able to test for genes known to be associated with the disease. This method not only clearly identifies the presence of a particular disease; it can also precisely determine the subtype of the disease. Throughout history,...

Single-cell RNA-seq could play a key role in personalized medicine by facilitating characterization of cells, pathways, and genes associated with human diseases such as cancer.