The spatial distribution of energy deposition events is an essential aspect in the determination radiobiological effects ionizing radiation at cellular level. Microdosimetry provides a theoretical framework for description these events, and has been used several studies to address problems such as characterization Linear Energy Transfer (LET) Relative Biological Effectiveness (RBE) ion beams pr...

Radiation is becoming widely available to treat tumors in veterinary patients. Orthovoltage machines capable of delivering low energy external beam radiation are less versatile than linear accelerators and cobalt-60 machines that deliver megavoltage radiation. In addition, electron beam capabilities that are available with some linear accelerators allow more targeted treatment in our smaller pa...

The risk of recurrence following radiation therapy remains high for a significant number of prostate cancer patients. The development of in vitro isogenic models of radioresistance through exposure to fractionated radiation is an increasingly used approach to investigate the mechanisms of radioresistance in cancer cells and help guide improvements in radiotherapy standards. We treated 22Rv1 pro...

Brain metastases represent the first cause of malignant brain tumor. Without radiation therapy, prognosis was poor with fast neurological deterioration, and a median overall survival of one month. Nowadays, therapeutic options depend on brain metastases presentation, extra brain disease, performance status and estimated prognostic (DS GPA). Therefore, for oligometastatic brain patients with a b...

The radiobiological effects of high atomic number and energy (HZE particles) ion beams are of interest for radioprotection in space and tumor radiotherapy. Space radiation mainly consists of heavy charged particles from protons to iron ions, which is distinct from common terrestrial forms of radiation. HZE particles pose a significant cancer risk to astronauts on prolonged space missions. With ...

Reverse-biased silicon p-n junction arrays using Silicon-On-Insulator technology have been proposed as microdosimeters. The performance of such detectors in boron neutron capture therapy (BNCT) is discussed. This work provides the first reported measurements using boron-coated silicon diode arrays as microdosimeters in BNCT. Results are in good agreement with measurements with gas proportional ...

Malignant thymomas are rare epithelial neoplasms of the anterior superior mediastinum that are typically invasive in nature and have a higher risk of relapse that may ultimately lead to death. Here we report a case of an advanced malignant thymoma that was successfully treated with neoadjuvant chemotherapy followed by surgical resection and subsequently with advanced and novel radiation therapy...

Reverse-biased silicon p-n junction arrays have been proposed as microdosimetry detectors. The tissue equivalence of such detectors in boron neutron capture therapy (BNCT) is discussed. A comparison of the range-energy relationships of H, He, C, and Li ions in tissue (ICRU-muscle) and silicon is given. A simple geometrical scaling (approximately 0.63) of linear dimensions is required to convert...

IMPORTANCE The treatment of multiple brain metastases (MBM) from melanoma is controversial and includes surgical resection, stereotactic radiosurgery (SRS), and whole-brain radiation therapy (WBRT). Several new classes of agents have revolutionized the treatment of metastatic melanoma, allowing some subsets of patients to have long-term survival. Given this, management of MBM from melanoma is c...