Bitterness is generally viewed as an undesirable attribute of foods and beverages, yet segments of the population regularly ingest items with a prominent bitter taste. The influence of taste sensitivity, exposure, selected personality traits (i.e., neophobia, variety seeking, sensation seeking) and pharmacological reactivity on alcohol and caffeine consumption, two widely consumed bitter substa...

The coronavirus assumed to have originated in Wuhan China, has infected millions of people since December 2019, resulting a pandemic. Recent changes symptoms are observed Covid-19 positive patients, whose were reported as fever, myalgia and cough the earlier cases. In this paper we presented two cases where initial symptom was loss taste smell sensation. Both these patients diagnosed pneumonia ...

The biological taste system has the unique ability to detect substances. Biomaterials originating from a have been recognized as ideal candidates serve sensitive elements in development of taste-based biosensors. In this study, we developed bud organoid-based biosensor for research sensation. Taste organoids prepared newborn mice were cultured and loaded onto surface 64-channel microelectrode a...

Combining unilateral denervation of anterior tongue taste buds with a low-sodium diet in rats results in a rapid, dramatic, and selective attenuation of neurophysiological sodium taste responses from the intact side of the tongue. The transduction pathway responsible for the attenuated response is through the epithelial sodium channel (Hill and Phillips, 1994). Current experiments extend these ...

Abstract Nonesterified fatty acids (NEFA) are effective taste stimuli. The quality they impart has not been well characterized. Sourness, and “fattiness” have reported, but an irritation component also described how these transition with gradations of aliphatic chain length systematically studied. This study examined intensity ratings NEFA ranging from C2 to C18. Oral sites the time course sens...

OBJECTIVES Terbinafine (Lamisil), a widely prescribed oral antifungal agent, reportedly induces taste loss in 0.6% to 2.8% of those taking the drug. However, many so-called taste problems reflect olfactory problems, and the sole empirical study published on this topic, based on whole-mouth testing of a single subject, found no terbinafine-related deficit. In this study, we quantitatively assess...

Recent molecular findings indicate that many different G-protein-coupled taste receptors that bind with "bitter-tasting" ligands are coexpressed in single taste receptor cells in taste buds, leading to the prediction that mammals can respond behaviorally to structurally diverse "bitter" tastants but cannot discriminate among them. However, recent in situ calcium-imaging findings imply that rat ...

Some amphipathic bitter tastants and non-sugar sweeteners are direct activators of G proteins and stimulate transduction pathways in cells not related to taste. We demonstrate that the amphipathic bitter tastants quinine and cyclo(Leu-Trp) and the non-sugar sweetener saccharin translocate rapidly through multilamellar liposomes. Furthermore, when rat circumvallate (CV) taste buds were incubated...

If for no other reason than the fact that eating and drinking gives us pleasure, it is of interest to understand the physiology of gustation. In this issue, Lyall et al. (2002a) have uncovered the key cellular mechanisms that occur in taste receptor cells (TRCs) when certain mixtures of chemicals (tastants) are applied to the anterior tongue. In much the same way as music produced by a quartet ...

Noxious pH triggers pungent taste and nocifensive behavior. While the mechanisms underlying acidic pH sensation have been extensively characterized, little is known about how animals sense alkaline pH in the environment. TMC genes encode a family of evolutionarily conserved membrane proteins whose functions are largely unknown. Here, we characterize C. elegans TMC-1, which was suggested to form...