Objective(s):Breast cancer is an important leading cause of death from cancer. Stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer. Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is the potential inhibitor of tau protein in neurons. This study determines the effect of memantine ...

Objective(s):Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. One of the hallmarks of AD is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. In this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in AD and tauopathies. Unfortunately, the available syntheti...

In the study of Fuchsian groups, it is a nontrivial problem to determine a set of generators. Using a dynamical approach we construct for any cocompact arithmetic Fuchsian group a fundamental region in SL2(R) from which we determine a set of small generators.

A temporal graph $${\mathcal {G}}$$ is a sequence of static graphs indexed by set integers representing time instants. Given $$\varDelta$$ an integer, -module vertices having the same neighbourhood outside for consecutive We address specific cases enumeration, when $$|A| = 2$$ or $$\varDelta \infty$$ . Our main parameter complexity analysis history length $$\tau \max \{t:G_t\in {\mathcal {G}}\t...

In this paper the periodic solutions of fourth order delay differential equation of the form $ddddot{x}(t)+adddot{x}(t)+f(ddot{x}(t-tau(t)))+g(dot{x}(t-tau(t)))+h({x}(t-tau(t)))=p(t)$  is investigated. Some new positive periodic criteria are given.