Taurine is involved in various physiological processes, and one of the most abundant amino acids in human. The aim was to investigate the mechanism for intestinal absorption of taurine in vivo using also in vitro mechanistic studies. Taurine absorption was measured in male Sprague-Dawley rats at 10-997 mg/kg and 1-30 mg/kg for oral and intravenous administration, respectively. Oral absorption w...

BACKGROUND In the recent years, various studies have shown a link between the free radicals, antioxidants and periodontal diseases. The purpose of the present study was to evaluate the oxidative stress and the antioxidant status present in the gingival tissue and plasma of patients with chronic periodontitis and to evaluate the antioxidant property of taurine. MATERIALS AND METHODS Periodonta...

The effects of a low protein diet on the excretion of sulfate and taurine, major metabolites of L-cysteine in mammals, were studied in rats fed with synthetic 10% (group A) and 25% (group B) casein diets. The average excretions of total taurine (taurine plus hypotaurine) and total sulfate (free plus ester sulfate) (mumol/kg of body weight per day after the adaptation to the synthetic diet) in g...

Taurine and zinc, highly concentrated in the retina, have neurotrophic effects in the central nervous system. Zinc modulates Na+/Cldependent transporters, such as those of dopamine and taurine (TAUT) in vitro, although there is no evidence of in vivo effects of zinc. The objectives of the present study were to evaluate the consequences of zinc deficiency on taurine levels and transport, and mRN...

Taurine has been demonstrated to be a conditionally indispensable nutrient for several carnivorous fish species. Currently, trout feeds contain reduced levels of fishmeal which had been the primary source of dietary taurine. The reduction of fishmeal in the diet, and thus dietary taurine, may limit growth. A 12-week feeding trial was conducted using a factorial treatment design with taurine sup...

Duchenne Muscular Dystrophy (DMD) is a fatal muscle wasting disease manifested in young boys, for which there is no current cure. We have shown that the amino acid taurine is safe and effective at preventing dystropathology in the mdx mouse model for DMD. This study aimed to establish if treating growing mdx mice with a higher dose of taurine was more effective at improving strength and reducin...

Because taurine alleviates ethanol- (EtOH-) induced lipid peroxidation and liver damage in rats, we asked whether exogenous taurine could alleviate EtOH-induced oxidative stress in chick embryos. Exogenous EtOH (1.5 mmol/Kg egg or 3 mmol/Kg egg), taurine (4 μmol/Kg egg), or EtOH and taurine (1.5 mmol EtOH and 4 μmol taurine/Kg egg or 3 mmol EtOH and 4 μmol taurine/Kg egg) were injected into fer...

Taurine has positive effects on bone metabolism. However, the effects of taurine on osteoblast apoptosis in vitro have not been reported. The aim of this study was to investigate the activity of taurine on apoptosis of mouse osteoblastic MC3T3-E1 cells. The data showed that 1, 5, 10, or 20 mM taurine resulted in 16.7, 34.2, 66.9, or 63.75% reduction of MC3T3-E1 cell apoptosis induced by the ser...

BACKGROUND Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, for which there is currently no safe and effective drug for therapy. In this study, we explored the effects of taurine, tea polyphenols (TPs), or a combination thereof, on NASH rats. METHODS Rats were divided into a normal group, a high-fat diet induced model group and a treatment group (...

The effects of [K+]o on taurine release from glial cells were studied with primary cultures of cerebellar astrocytes and with LRM55 cells, a continuous glial cell line. The characteristics of K(+)-stimulated taurine release were virtually identical in the 2 cell types. Both cerebellar astrocytes and LRM55 cells released taurine when stimulated with high-K+ medium prepared by isosmotically subst...