Dl-lsoleucine was complexed with Thioglycolic acid in the presence of Stannous ions to label with TC99m-Pertechnetate. Percentage labeling was determined by paper chromatography. Preparations of more than 95% labeled with Tc99m were injected to rabbits for imaging and tissue distribution studies. Tc99m.TGA.l LEU complex was investigated as a myocardial imaging agent with respect to its kinetics...

OBJECTIVES This study aims primarily to determine whether whole body MRI (WB-MRI) and Sestamibi Technetium-99m-bone marrow (MIBI) scans in the same patients produce the same estimate of disease load and location, and secondly, to study possible association between the bone disease detected by these scans and the effect on disease outcome and survival. Bone disease occurs in about 90% of multipl...

To compare the myocardial uptake pattern of 99mTc-labeled methoxyisobutyl isonitrile [( 99mTc] MIBI) and 201TI, planar scintigraphy were performed in both patients with documented coronary artery disease and subjects with a low likelihood of disease. Quantitative analysis was employed using a standard interpolative background subtraction algorithm and a new algorithm modified to better accommod...

PURPOSE To compare the diagnostic value of 99Tcm-MIBI- SPECT and 18F-FDG-PET/CT in differentiating benign from malignant solitary pulmonary nodules (SPNs). METHODS 170 SPNs were involved in this study (78 with 99Tcm-MIBI-SPECT and 92 with 18F-FDG-PET/CT). Definite diagnosis of SPNs was determined by biopsy. The diagnostic efficiency of 99Tcm-MIBI-SPECT and 18F-FDGPET/ CT in differentiating be...

introduction: it is recommended that the physician apply at least a semi-quantitative segmental scoring system in myocardial perfusion spect.  we aimed to assess the agreement between automated semi-quantitative analysis using qps (quantitative perfusion spect) software and visual approach for calculation of summed stress  score (sss), summed rest score (srs) and summed difference score (sds). ...

BACKGROUND The aim of this study was to evaluate the value of semiquantitative analysis (SQA) of 99mTc-MIBI imaging in predicting early-stage cervical lymph node metastasis (CLNM) in thyroid carcinoma (TC). MATERIAL AND METHODS TC patients (n =106) undergoing surgical resection and histopathological examination were enrolled. All patients received 99mTc-MIBI imaging prior to surgery. P-glycopro...

BACKGROUND We investigated a novel technique, intraoperative (99 m)Tc-Sestamibi (MIBI) imaging (neck and excised specimen (ES)), using a large field-of-view portable gamma camera (LFOVGC), for expediting confirmation of MIBI-avid parathyroid adenoma removal. METHODS Twenty patients with MIBI-avid parathyroid adenomas were preoperatively administered MIBI and intraoperatively imaged prior to i...

In a canine model of reperfused myocardial infarction, we tested the hypothesis that after reperfusion, technetium-99m-hexakis-2-methoxyisobutyl isonitrile (Tc-MIBI) tomographic imaging still reflects occlusion blood flow when the tracer is injected before reperfusion. Nine anesthetized dogs underwent 2 hours of coronary occlusion followed by 3 hours of reperfusion ending by being killed. Refer...

OBJECTIVE To determine the frequency of the types of parathyroid gland hyperplasia and the sensitivity of sestamibi-(99m)Tc (MIBI) scintigraphy and ultrasonography (US) of patients with secondary hyperparathyroidism (SHPT) due to chronic renal failure. MATERIAL AND METHODS We studied 43 patients with SHPT (26 females and 17 males with age range of 27-75 years). Blood tests were performed to d...

OBJECTIVE Tc-methoxyisobutyl isonitrile (MIBI) has been reported to show considerable clinical utility in the study of many neoplastic diseases. The aim of our study was to investigate the possible role of Tc-MIBI in the initial follow-up of patients with differentiated thyroid cancer (DTC) for detecting residual thyroid uptake and/or loco-regional/distant metastases. METHODS Eighty-two patie...