Previous studies in our laboratory showed a synergistic interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in regard to teratogenic effects produced in mice (M. M. Elmazar et al., 2001, TOXICOL: Appl. Pharmacol. 170, 2-9). In the present study the influence of phytol and phytanic acid (a RXR-selective ligand) on the teratogenicity of retinol and the RAR-selective ...

Azarbayjani, F. 2001. Common mechanism for teratogenicity of antiepileptic drugs. Drug induced embryonic arrhythmia and hypoxia-reoxygenation damage. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculy of Pharmacy 253. 54 pp. Uppsala.

DEPARTMENT OF PESTICIDE REGULATION MEDICAL TOXICOLOGY BRANCH SUMMARY OF TOXICOLOGY DATA DIAZINON Chemical Code # 198, SB 950-204, Tolerance # 00153 July 29, 1986 Revised 6/16/88, 2/17/89, 2/27/90, 12/28/93, 8/20/96, 7/21/98, 4/15/99 I. DATA GAP STATUS Chronic toxicity, rat: No data gap, no adverse effect Chronic toxicity, dog: No data gap, no adverse effect Oncogenicity, rat: No data gap, no ad...

Valproate (VPA) is one of several effective anti-epileptic and mood-stabilizing drugs, many of which are also potent teratogens in humans and several other mammalian species. Variable teratogenicity among inbred strains of laboratory mice suggests that genetic factors influence susceptibility. While studying the genetic basis for VPA teratogenicity in mice, we discovered that parental factors i...

Women who receive transplants require contraception counseling because of the teratogenicity of immunosuppressant medications and the risks posed by pregnancy after transplant. Fortunately, pregnancy can succeed with careful planning and monitoring.

valproic acid is one of the main antiepileptic drugs. there is an increased risk of neural tube defects and axial skeletal malformations among infants born to women who had received valproic acid. there is a hypothesis that one biochemical abnormality underlying the teratogenicity of valproic acid is a drug-induced reduction in maternal plasma zinc .in the present experimental study mated rats ...

objective(s): anti-epileptic drugs (aeds) have the potential to affect fetal development throughout pregnancy. considering the broad therapeutic indications of pregabalin (pgb), its potential teratogenic effects and the levels of homocysteine have been studied.   materials and methods: timed-pregnant mice received one of three doses of pgb (20, 40 or 80 mg/kg/day) or the vehicle control during ...