N'-glycyl derivative (4) of antibiotic 67-121-C was prepared from the N'-iodoacetate (2) by treatment with aqueous ammonium hydroxide (Scheme 1). This compound was found to be slightly more potent than the parent antibiotic. This was particularly significant as simple N-acyl derivatives (e.g. N'-acetyl) of antibiotic 67-121-C and of other polyene antibiotics have all proved to be much less pote...

A new tris-(2-aminoethyl)amine (TREN) capped tripodal Schiff base ligand has been developed by mimicking structural features of a natural siderophore, Bacillibactin, by substituting the catechol units with salicylaldehyde and employing amino acid as spacer. Synthesis of the ligand N-[2-[bis[2-[[2-[(2-hydroxyphenyl)methylamino]acetyl] amino]ethyl]amino]ethyl]-2-[(2-hydroxyphenyl)methylamino]...

Analysis of amino acid sequences can provide useful insights into the tertiary structures of proteins and their biological functions. One of the critical problems in amino acid analysis is how to establish a digital coding system to better reflect the properties of amino acids and their degeneracy. Based on the hydrophobic index, a one-to-one relationship has been established between the amino ...