Thiourea is the parent compound of a group of compounds known t.o have goitrogenic activity. These substances prevent the formation of organically bound iodine from iodide ion (l-6), but the mechanism of this action is unknown. ‘Paper I of this series (7) showed that when thiourea labeled with radioactive sulfur was administered to rats the concentration of radioactivity in the thyroid gland 24...

Crystalline N-alkyl-N-arylthioureas with ortho hydroxyl and para or meta methyl substituents to the phenyl ring were studied by single crystal X-ray diffraction, IR and solid state C CP MAS NMR. Two different modes of association were found: i) intermolecular NH...S bonds and NH not involved in hydrogen bonding in N-methyl-N(2-hydroxy,5-methylphenyl)thiourea 1, ii) cyclic dimers with two NH...S...

Facilitated SO4(2-) transfers by hydrogen bond-forming ionophores are investigated across the nitrobenzene (NB)-water interface by using polarography with a dropping electrolyte electrode. Bis-thiourea 1, alpha,alpha'-bis(N'-p-nitrophenylthioureylene)-m-xylene, is found to significantly facilitate the transfer of the highly hydrophilic SO4(2-) whereas its counterpart, N-(p-nitrophenyl)-N'-propy...

We assessed in this work how a chemical structure difference could influence a supramolecular organization and then its biological properties. In our case study, we considered two amphiphilic lipidic gene vectors. The chemical difference was situated on their hydrophilic part which was either a pure neutral thiourea head or a mixture of three thiourea function derivatives, thiourea, iminothiol,...

With the notable exceptions of water, ammonia and a very limited number of other examples, there have been relatively few highpressure structural studies of simple molecular compounds. Such studies can provide fascinating information about intermolecular interactions and pressure-induced phase transition, in particular hydrogen-bonding interactions. Recent results for thiourea and urea obtained...

l-Glutamate uptake, thiourea uptake, and methylammonium uptake and the intracellular ammonium concentration were measured in wild-type and mutant cells of Aspergillus nidulans held in various concentrations of ammonium and urea. The levels of l-glutamate uptake, thiourea uptake, nitrate reductase, and hypoxanthine dehydrogenase activity are determined by the extracellular ammonium concentration...

Since Gordon et al.(1943)reported that amphibian metamorphosis is effectively inhibited by thiourea treatment,a considerable number:of studies have been made by many investigators to examine the effects of antithyroidal substances on amphibian larvae.Most of them,however,dealt with only the inhibition of metamorphosis or the dipigmentation,and no description on the gonads of the treated larvae ...