Transforming growth factors (TGFs)are multipotent in their biologic activity, regulating cell growth and differentiation as well as extracellular matrix deposition and degradation. Most of these activities involve modulation of gene transcription, but TGF1 has been shown previously to substantially increase the expression of elastin by stabilization of tropoelastin mRNA through a signaling path...

The effect of genetic polymorphisms in the TGF1 gene at codon 10 (T 29C), codon 25 (G 74C), and the promoter region [C 3 T at 509 from the transcription site, (C-509T)] on breast cancer survival was evaluated among a cohort of 1111 patients. The median follow-up time for the cohort was 5.17 years after cancer diagnosis. No DNA sequence variation at codon 25 of the TGF1 gene was found, whereas p...

Galarreta CI, Thornhill BA, Forbes MS, Simpkins LN, Kim DK, Chevalier RL. Transforming growth factor1 receptor inhibition preserves glomerulotubular integrity during ureteral obstruction in adults but worsens injury in neonatal mice. Am J Physiol Renal Physiol 304: F481–F490, 2013. First published January 9, 2013; doi:10.1152/ajprenal.00496.2012.—Unilateral ureteral obstruction (UUO), a widely ...

Purpose: The aim of this study was to compare a new method for the production of platelet-rich plasma (PRP), the plasma-rich-in-growth-factors kit (PRGF kit; G.A.C. Medicale San Antonio, Vitoria, Spain), with an established method, the Platelet Concentrate Collection System (PCCS; 3i/Implant Innovations, Palm Beach Gardens, FL) with respect to resulting cellular and growth factor contents. Mate...

Luo, Xiaoping, Li Ding, and Nasser Chegini. Gonadotropinreleasing hormone and TGFactivate MAP kinase and differentially regulate fibronectin expression in endometrial epithelial and stromal cells. Am J Physiol Endocrinol Metab 287: E991–E1001, 2004. First published July 20, 2004; doi:10.1152/ajpendo.00200.2004.—Gonadotropin-releasing hormone analog (GnRHa) is used for medical management of endo...

A NUMBER OF MOLECULES using different transforming growth factor (TGF)1-induced signaling pathways are involved that activate a wide variety of cells leading to a terminal event known as “scarring or fibrosis” in various organ systems. Likewise, renal fibrosis is an inevitable consequence of various types of progressive chronic kidney diseases (CKD), and it is characterized by continued exacerb...

Avraham T, Yan A, Zampell JC, Daluvoy SV, HaimovitzFriedman A, Cordeiro AP, Mehrara BJ. Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF1-mediated tissue fibrosis. Am J Physiol Cell Physiol 299: C589 –C605, 2010. First published June 2, 2010; doi:10.1152/ajpcell.00535.2009.—Although radiation therapy is a major risk factor for the developme...

Noh H, Oh EY, Seo JY, Yu MR, Kim YO, Ha H, Lee HB. Histone deacetylase-2 is a key regulator of diabetesand transforming growth factor1-induced renal injury. Am J Physiol Renal Physiol 297: F729 –F739, 2009. First published June 24, 2009; doi:10.1152/ajprenal.00086.2009.—Excessive accumulation of extracellular matrix (ECM) in the kidneys and epithelial-tomesenchymal transition (EMT) of renal tub...

Peyronie’s disease is an idiopathic, localized connective tissue disorder of the penis, involving the tunica albuginea of the corpus cavernosum and adjacent areolar space. Current proposals as to the origin of Peyronie’s disease suggest that fibrosis and collagen changes of the tunica are the result of an inflammatory process following vascular trauma. Our laboratory and other investigators hav...

Zhang, Aihua, Zheng Dong, and Tianxin Yang. Prostaglandin D2 inhibits TGF1-induced epithelial-to-mesenchymal transition in MDCK cells. Am J Physiol Renal Physiol 291: F1332–F1342, 2006. First published August 8, 2006; doi:10.1152/ajprenal.00131.2006.—In a separate study, we identified PGE2 as a potent inhibitor of TGF1-induced epithelial-mesenchymal transition (EMT) in cultured Madin-Darby cani...