Abstract Scleroderma is an autoimmune disease that causes dermal fibrosis. It occurs when collagen accumulates in tissue as a result of persistent inflammation. Th17 cells and pro-inflammatory cytokines such IL-1?, IL-6, IL-17, TNF-? play important roles the pathogenesis scleroderma. Because metformin, medication used to treat diabetes, has effective immunoregulatory functions, we investigated ...

Chronic inflammatory diseases are characterized by local tissue injury caused by immunocompetent cells, in particular CD4(+) T lymphocytes, that are involved in the pathogenesis of these disorders via the production of distinctive sets of cytokines. Here, we have characterized single CD4(+) T cells that infiltrate inflamed tissue taken from patients with psoriasis, Crohn's disease, rheumatoid a...

Multiple sclerosis (MS) is the most common chronic demyelinating disease of central nervous system (CNS), with an autoimmune inflammatory mechanism, but immunological analysis, described in pathogenesis disease, not attributed or significantly placed universally used criteria. In this regard, literature review aims to highlight aspects that can be both diagnosis and treatment MS. sense, compile...

BACKGROUND Several types of T cells have been associated with the pathogenesis of unexplained recurrent spontaneous abortion (URSA), including Th1/Th2/Th17/Tregs cell. It has been appreciated that immunotherapy with paternal or third party lymphocytes is an effective method of treatment for URSA patients. The balance of Th1/Th2 cells could be maintained and an increase of Treg cells would be be...

We read with interest the recent paper by Facco et al which showed that Th17 cells are present in blood, bronchoalveolar lavage (BAL) and lung tissue from people with sarcoidosis. The authors conclude that Th17 cells are involved in the pathogenesis of sarcoidosis as a multisystem disorder. Interestingly, the paper mentions expression of interleukin (IL)-17 protein by macrophages. Currently, a ...

T helper 17 (Th17) cells play a complex and controversial role in tumor immunity and have been found to exhibit a fluctuating identity within the context of cancer. The recent, expanding literature on these cells attests to their puzzling nature, either promoting or suppressing tumor growth depending on the malignancy and course of therapeutic intervention investigated. This review addresses se...

Psoriasis is a chronic inflammatory skin disease characterized by increased proliferation of epidermal cells, impaired keratinization and an reaction in dermis caused activation T lymphocytes synthesis pro-inflammatory cytokines. The pathophysiology psoriasis also associated with decrease anti-inflammatory functions immunosuppressive cells. Recently, there are more cases development resistance ...

BACKGROUND Exercise training positively influences exercise tolerance and functional capacity of patients with idiopathic pulmonary arterial hypertension (IPAH). However, the underlying mechanisms are unclear. We hypothesized that exercise modulates the activated inflammatory state found in IPAH patients. METHODS Single cardiopulmonary exercise testing was performed in 16 IPAH patients and 10...

The protein kinase C (PKC) family of serine-threonine kinases plays a central role in T lymphocyte activation. Here, we identify NR2F6, a nuclear zinc-finger orphan receptor, as a critical PKC substrate and essential regulator of CD4(+) T cell activation responses. NR2F6 potently antagonized the ability of T helper 0 (Th0) and Th17 CD4(+) T cells to induce expression of key cytokine genes such ...

BACKGROUND There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 cells has been suggested. METHODS The study aimed (1) to investigate the phenotypical and functional characteristics of Th17 and Tregs in SSc patients dependi...