نتایج جستجو برای: thalassemic patient
تعداد نتایج: 710072 فیلتر نتایج به سال:
The pathophysiology of thalassemia is, to a certain extent, associated with the generation of labile iron in the pathological red blood cell (RBC). The appearance of such forms of iron at the inner and outer cell surfaces exposes the cell to conditions whereby the labile metal promotes the formation of reactive oxygen species (ROS) leading to cumulative cell damage. Another source of iron accum...
Introduction: Noting children's behavioral problem,‎‏ ‏which formats major forms of children ‎psycho-pathology in all culture and human communities, is very important because most adult ‎behavioral disorder originates from primary experiences in childhood. Behavioral problem ‎have different reasons and one of these reasons are chronic physical illnesses such as major b-&...
introduction: leptin is an adipocyte-derived hormone. exogenous leptin allows the recovery of the reproductive function. in humans, leptin correlates positively with the body mass index (bmi). the aim of this study was to investigate the association of leptin with the toxic effects of iron overload. methods: 219 major beta thalassemic patients (119 men, 100 women) and 137 non thalassemic indivi...
OBJECTIVE In thalassemic children, HBV infection is common, thus immunization against HBV will reduce and prevent the rate of infection. The aim of this study was to evaluate the efficacy of HBV immunization and the prevalence of HBV infection in beta-thalassemic children in Tehran. METHODS To assess the efficacy of immunization and determine the immune response of children with beta-thalasse...
UNLABELLED This work was carried out to investigate the role of Glutathione S-Transferase M1 (GSTM1) null genotype frequency in prognosis of β-thalassemia, and to detect the correlation between GSTM1 null genotype and appearance of cardiac complications in β-thalassemia. MATERIALS AND METHODS The studied groups in the present work were divided to three groups (group I: 20 healthy subjects, gr...
We have examined aspects of methemoglobin (metHb) reduction in sickle and in thalassemic red blood cells (RBCs). NADH metHb reductase activity in sickle and thalassemic RBCs was significantly increased compared with normal RBCs. Because in vitro enzyme activity does not necessarily represent in vivo activity, we measured the rate of metHb reduction in intact RBCs. Intact thalassemic RBCs demons...
INTRODUCTION Extramedullary hematopoiesis occurs in approximately 15% of cases of thalassemia. Intracranial deposits of extramedullary hematopoiesis are an extremely rare compensatory process in intermediate and severe thalassemia. CASE PRESENTATION We present an unusual case of an intracranial extramedullary hematopoiesis with a choroid plexus origin in a 34-year-old Caucasian man with beta ...
introduction: the coagulation factor 13 has a fundamental role in homeostasis, protective effects on thrombosis, and some other associated diseases. due to increasing the chronic coagulability of major thalassemic patients, this study was conducted with aim determining the prevalence of val34leufxiii polymorphism in the thalassemic patients. materials and methods: the present case-control study...
In vivo correction of anaemia in beta-thalassemic mice by gammaPNA-mediated gene editing with nanoparticle delivery" (2016).
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