Ovarian tumours are rare in children and account for approximately 1% of all the tumours of childhood (Schultz, 1926). The majority are benign, the commonest being cystic teratoma. Tumours causing sexual precocity and pseudoprecocity are particularly rare; Wilkins (1957), in a long experience of paediatric endocrinology, personally encountered only one case. The ovarian tumour most often respon...

The aim of this study was to assess and compare the steroidogenic response to luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in cells of the theca interna and theca externa isolated from follicles at different stages of maturation. Cells of the theca interna and theca externa isolated from the largest, second largest and third-fifth largest preovulatory follicles of the chicken...

BACKGROUND Steroid cell tumors of ovary account for less than 0.1% of all ovarian tumors and these tumours may present at any age in association with interesting presentations related to hormonal activities. The subtype, not otherwise specified (NOS), is associated with androgenic changes in 56-77% and Cushing syndrome in 6-10%. Due to the rarity of available data regarding these tumors, little...

The direct actions of kit-ligand/stem cell factor (KL) in developing ovarian follicles were investigated. Previous studies have shown that granulosa cells express KL that can support oocyte development. The current study demonstrates that KL can also act directly on theca cells to promote cellular growth and differentiation. Through RT-PCR analysis it was shown that bovine granulosa cells expre...

The ovary is itself a hormone secreting organ, and it has been shown that some ovarian tumors also secrete hormones. Granulosa cell tumors and theca cell tumors are hormone secreting tumors. There have been many reports on the histogeneses, character, and nomenclatures of these tumors. In 1944, Biskind et al. reported the development of granulosa cell tumors and luteoma by intrasplenic ovarian ...

The distribution of binding sites for human chorionic gonadotropin (hCG) in the preovulatory follicle was studied by autoradiography. An ovulatory dose (10 IU/rat) of [125I]hCG (1.4 muCi/IU) was administered intravenously, and large Graafian follicles were isolated 3 h later by microdissection. Injection of excess unlabeled hCG (500 IU/rat) prevented uptake of radioactivity by the follicle, ind...

S100 proteins comprise a large family of Ca(2+)-binding proteins and exhibit a variety of intra- and extracellular functions. Despite our growing knowledge about the biology of S100 proteins in some tissues such as brain and smooth muscle, little is known about S100 proteins in the normal mammalian reproductive tissue. In the present study, we investigated the distribution pattern of S100A6 (al...

Histochemical and ultrastructural studies of gonads from goldfish Carassius auratus and several species of salmon (genus Oncorhynchus) indicate that the Leydig or interstitial cells of the testis and special cells of the theca interna of the ovary are the major sources of gonadal steroids. Lobule boundary cells are considered homologous with the Sertoli cells of the testis and the granulosa cel...

The aim of this study was to determine how luteal cells of the hormone-primed (luteinized) ovary process low density lipoproteins (LDL). Ovary uptake of perfused 125I-LDL was assessed by tissue levels of radioactivity; the distribution of LDL protein in cells was assessed on autoradiograms of the fixed tissue; and the level of stimulation of steroidogenesis, as well as degradation of LDL protei...