OBJECTIVES Therapeutic drug monitoring (TDM) of voriconazole is recommended to achieve trough concentrations of 1-5 mg/L. In children, this is challenging due to age-related variability in voriconazole pharmacokinetics. This study describes our experience with voriconazole, focusing on dosing regimens, dose adjustment and TDM. METHODS We reviewed the medical records of immunocompromised child...

Introduction and aim: Therapeutic drug monitoring (TDM) of vancomycin aims to achieve an optimal response minimize the risk toxicity by keeping plasma levels within therapeutic range. In this study, we aimed evaluate treatment appropriateness TDM in patients receiving vancomycin. 
 Method: For purpose, who received ICUs a university hospital during 8-month period between January August 202...

Therapeutic drug monitoring (TDM) or the measurement of drug concentrations in plasma, serum or blood, aims to improve clinical activity, avoid toxicity, and reduce the costs of drug treatment. Specific conditions for TDM to be reasonably applied include the availability of a validated assay, a considerable inter-individual pharmacokinetic variability, a high correlation between drug concentrat...

In 2022, we opened an outpatient clinic for the management of polypharmacy and potential drug–drug interactions (pDDIs) in patients with mycobacterial infection (called GAP-MyTB). All who underwent a GAP-MyTB visit from March 2022 to 2023 were included this retrospective analysis. Fifty-two database. They given 10.4 ± 3.7 drugs (2.8 1.0 7.8 3.9 were, respectively, antimycobacterial agents co-me...

Background: Pharmacokinetic nomograms, equations, and software are considered the main tools available for Therapeutic Drug Monitoring (TDM). Model-informed precision dosing (MIPD) is an advanced discipline of TDM that allows dose individualization, requires a knowledge integration statistical calculations. Due to its extensive applicability, use these widespread in clinical practice. However, ...

Surface-Enhanced Raman Spectroscopy (SERS) is a label-free technique that enables quick monitoring of substances at low concentrations in biological matrices. These advantages make it an attractive tool for the development of point-of-care tests suitable for Therapeutic Drug Monitoring (TDM) of drugs with a narrow therapeutic window, such as chemotherapeutic drugs, immunosuppressants, and vario...

SUMMARY Clozapine dose assessment in treatment-refractory schizophrenia is complicated. There a narrow margin between an effective and potentially toxic wide inter-individual variation clozapine metabolic capacity. Moreover, factors such as changes smoking habit, infection/inflammation, co-prescription of certain drugs, notably fluvoxamine, age alter the requirement within individuals. Therapeu...

BACKGROUND Gentamicin and vancomycin are commonly used in neonatal units for the treatment of life-threatening infections. This study aimed to describe the dosage regimen and the approach to therapeutic drug monitoring (TDM) for both antibiotics in units that participate in a UK neonatal network. METHODS Questionnaires were sent to all units across the Extended Neonatal Network, requesting de...