Cisplatin administration is frequently associated with renal insufficiency and tubular dysfunction. In this article, a case of massive cisplatin overdose as a result of an accidental substitution for carboplatin is reported. The patient developed oliguric renal failure, hepatotoxicity, ototoxicity, peripheral neuropathy, blindness, and severe myelosuppression. A therapeutic trial with N-acetylc...

background: proteolytic enzymes have an important role in variety of physiological and pathological functions. they have been used in therapeutic and pharmaceutical applications. characterizations of extracellular proteases from various strains of s. marcescens indicate that most strains produce a very similar major metalloprotease. this metalloprotease (serrapeptidase, serrapeptase) is an impo...

background and aims: crocus sativus is of medicinal plants possessing many beneficial effects in treatment of various disorders. this study aimed to overview the therapeutic effects of crocus sativus on the basis of reviews and systematic reviews. methods: computerized search of review articles was performed using pubmed, google scholar, scopus and web of science, medline database from 1996 to ...

background: cd52 is a small glycoprotein with a gpi anchor at its c-terminus. cd52 is expressed by normal and malignant t and b lymphocytes and monocytes. there are detectable amounts of soluble cd52 in plasma of patients with cll and could be used as a tumor marker. although the biological function of cd52 is unknown but it seems that cd52 may be involved in migration and activation of t-cells...

background: we evaluated the in vivo activity of bunium persicum (boiss) essential oil on infected mice with acute toxoplasmosis. methods: to evaluate prophylactic effects, male nmri mice received b. persicum essential oil at the concentrations of 0.05 and 0.1 ml/kg for 14 days . after 24 h mice were infected intraperitonealy with 1×10 4 tachyzoites of t. gondii, rh strain. in order to investig...

abstract background: nausea and vomiting are the worst and the most prevalent complications experienced by 70–80% of patients. complementary treatments including therapeutic touch are cost‑effective and low‑risk, independent nursing interventions. present research aims at investigating the effect of therapeutic touch on the intensity of acute chemotherapy‑induced vomiting in these patients. mat...

abstract background: hypertension has become a major problem throughout the world, especially in developing countries like iran. as it is a major risk factor for coronary heart disease, even small reductions in the prevalence can have potentially large public health benefits. among the complementary methods, massage provides an effective means to lower the blood pressure. if nurses perceive the...

BACKGROUND Mandatory generic substitution was introduced in Sweden in October 2002 in order to try to curb escalating pharmaceutical expenditure. The aim of this study was to investigate how sales patterns for substitutable and non-substitutable pharmaceuticals have developed since the introduction of mandatory generic substitution; furthermore, to compare sales patterns in different groups of ...