Arsenic trioxide (As(2)O(3)) is a highly effective treatment for patients with relapsed acute promyelocytic leukemia (APL); its role as consolidation treatment for patients in first remission has not been defined. We randomized 481 patients (age ≥ 15 years) with untreated APL to either a standard induction regimen of tretinoin, cytarabine, and daunorubicin, followed by 2 courses of consolidatio...

Arsenic trioxide (As2O3) is a highly effective treatment for patients with relapsed acute promyelocytic leukemia (APL); its role as consolidation treatment for patients in first remission has not been defined. We randomized 481 patients (age > 15 years) with untreated APL to either a standard induction regimen of tretinoin, cytarabine, and daunorubicin, followed by 2 courses of consolidation th...

The effect of thermal contact resistance (TCR) correlated to the degree intimate (DIC) between incoming tape and substrate on temperature history during laser-assisted fiber placement (LAFP) was investigated. A novel experimental methodology designed understand with a non-contact method which did not influence local consolidation quality. To assess TCR numerically, three-dimensional optical-the...

Numerous factors affect motor learning, and its subsequent consolidation into effortlessly retrievable motor memories. Evidence from sleep research suggests a role for sleep in motor learning and motor memory consolidation. Optimal motor performance on a recently learned task is facilitated by sleepmediated consolidation of motor memories. Yet, sleep independent motor memory consolidation occur...

A design sensitivity method is used to find optimal autoclave temperature and pressure histories for curing of thermoset-matrix composite laminates. The method uses a finite element simulation of the heat transfer, curing reaction, and consolidation in the laminate. Analytical sensitivities, based on the direct differentiation method, are used within the finite element simulation to find the de...

the central cholinergic system has been associated with cognitive function and memory and acetylcholine plays an important role during the early stages of memory consolidation. in this study, after training mice were tested with one way active avoidance procedure and retention were tested at 4, 8, 12, 16 and 24 hours of training and compared with non-shocked mice, in which it took 24 hours, a s...

Micro-convection is a strategic area in transport phenomena, since it is the basis for a wide range of miniaturised high-performance applications. Microchannel heat-sinks are appealing solutions to the increasing heat dissipation demands, especially in electronic devices. Literature reveals that in the single-phase continuum regime, the behaviour of micro-convection significantly differs from t...

During the 1990s, the hospital industry was transformed by mergers and acquisitions. This synthesis looks at why this rapid consolidation occurred and what impact it had on the price and quality for patients, and the cost of care for hospitals. Key findings include: Managed care was not a main driver of consolidation, but fear of managed care may have played a part. Other factors, including tec...