Pain signaling in vertebrates is modulated by neuropeptides like Substance P (SP). To determine whether such modulation is conserved and potentially uncover novel interactions between nociceptive signaling pathways we examined SP/Tachykinin signaling in a Drosophila model of tissue damage-induced nociceptive hypersensitivity. Tissue-specific knockdowns and genetic mutant analyses revealed that ...

This paper proposes a coupled thermal-hydrological-mechanical damage (THMD) model for the failure process of rock, in which coupling effects such as thermally induced rock deformation, water flow-induced thermal convection, and rock deformation-induced water flow are considered. The damage is considered to be the key factor that controls the THM coupling process and the heterogeneity of rock is...

The mechanisms thought to be responsible for the laser-induced reaction in biological tissues are thermal effects, mechanical effects, and electromagnetic field effects. In the retina all damage is associated with a disturbance of the pigmented layer, the pigment epithelium, and no evidence is found of primary damage in the neural layers. This indicates that the photonabsorption mechanism is a ...