BackgroundThe interaction of allergens and allergen-specific IgE initiates the allergic cascade after crosslinking receptors on effector cells. Antibodies other isotypes may modulate such a reaction. Receptor requires binding antibodies to multiple epitopes allergen. Limited information is available complexity epitope structure most allergens.ObjectivesWe sought allow description IgE, IgG4, IgG...

background: several studies reported the clinical features of ige-mediated hypersensitivity after ingestion of melon. melon allergy is a common ige-mediated fruit allergy in iran. this prompted us to investigate immunochemical and molecular properties of the major allergen in melon fruit, to compare the ige-binding capacity of the natural protein with the recombinant allergen, and to determine ...

objective(s):sublingual allergen-specific immunotherapy is a safe and effective method for treatment of ige-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. this study was planned to test whether sublingual immunotherapy (slit) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. materials and methods:balb/c...

In the 90's of the XX century, 2 new and important allergens of house dust mites mites were cloned and sequenced: Mag 1 and Mag 3. However, the second allergen has been identified to date only in extracts of Dermatophagoides farinae [DF ]. In this work, we aimed to detect expression of this important allergen and for the first time analyze to the amino acid sequence in other species of house du...

BACKGROUND Grass pollen immunotherapy is an effective treatment for seasonal allergic rhinitis that provides the opportunity to study the induction and maintenance of allergen-specific immune tolerance. OBJECTIVES We investigated the relationship between clinical responsiveness, regulatory cytokine production, and antibody responses to allergen during 1 year of immunotherapy. METHODS Eighte...

The bird feather vane can be separated into two parts by pulling the barbs apart. The original state can be re-established easily by lightly stroking through the feather. Hooklets responsible for holding vane barbs together are not damaged by multiple zipping and unzipping cycles. Because numerous microhooks keep the integrity of the feather, their properties are of great interest for understan...

BACKGROUND Allergen measurements are widely used for environmental exposure assessments and for determining the potency of allergen vaccines, yet few purified allergen standards have been developed. The aim of the study was to develop a single standard containing multiple purified allergens that could be used in enzyme immunoassays and in multiplex arrays for the standardization of allergen mea...

Immunoglobulin (Ig) E-mediated sensitization to domestic inhalant allergens (eg, dust mite, cockroach, cat, and dog) is the most important risk factor for asthma. The severity of asthma increases among atopic patients exposed to high levels of sensitizing allergen. In addition, synergism between high allergen exposure and respiratory virus infection increases the risk of asthma exacerbation. Ho...