The 3-thia fatty acids, tetradecylthioacetic acid and 3,10-dithiadicarboxylic acid are mitochondrion and peroxisome proliferators. Administration of these promotes an increased transport of endogenous fatty acids to these organelles and a higher capacity of beta-oxidation. Administration of 3-thia fatty acids to rats resulted in a significant decrease of the hepatic level of docosahexaenoic aci...

The 21,23-dithia and 21-thia analogues of phlorins and mono-functionalized thiaphlorins were synthesized using easily available precursors and the mono-functionalized thiaphlorins were used further to synthesize the first examples of three covalently linked thiaphlorin-porphyrin dyads.

In the title compound, C19H14FNS2, the seven-membered thia-zepine ring adopts a slightly distorted twist boat conformation. The dihedral angle between the benzene rings is 53.6 (1)°. The mean plane of the thia-zepine ring is twisted by 34.3 (7)° and 36.6 (7)° from the benezene rings. A C-H⋯F interaction generates stacking of molecules along the ab plane.

In the title compound, C12H12N2OS, the dihedral angle between the benzene and thia-zole rings is 83.5 (7)°. The acetamide group is almost coplanar with the thia-zole ring, being twisted from it by 4.2 (9)°. In the crystal, pairs of N-H⋯N hydrogen bonds link mol-ecules into inversion dimers, generating R 2 (2)[8] loops; the dimers are stacked along [001].

In the title compound, C13H19N3S, the methyl-amine substituent is coplanar with the thia-diazole ring to which it is attached [C-N-C-S torsion angle = 175.9 (2)°] and the amine H atom is syn to the thia-diazole S atom. Supra-molecular chains along [101], sustained by N-H⋯N hydrogen bonding, feature in the crystal packing.

The title compound, C(16)H(12)ClN(3)S, was synthesized by the reaction of 5-(4-methyl-phen-yl)-1,3,4-thia-diazol-2-amine and 4-chloro-benzaldehyde. The thia-diazole ring is essentially planar with mean deviation of 0.0042 Å.

In the title compound, C(19)H(16)N(4)S(4), the mol-ecules exhibit a butterfly conformation, where the thia-diazole and attached benzene rings in two wings are almost coplanar, with dihedral angles of 0.8 (3) and 0.9 (3)°, respectively, while the two thia-diazole rings form a dihedral angle of 46.3 (3)°.

In the title compound, C(14)H(17)NO(5)S, the thia-zine ring adopts a half-chair conformation. The mol-ecule exhibits an intra-molecular O-H⋯O hydrogen bond, which forms a six-membered S(6) ring motif. The planes of the benzene and thia-zine rings are inclined at a dihedral angle of 15.30 (12)°.

In the title compound, C(8)H(9)N(3)S(2), the n-propyl chain is disordered over two orientations (site-occupancy ratio = 0.522:0.478) and is roughly perpendicular to the fused thia-zolotriazine system. The angle between the fused ring and the propyl chain is 83.6 (1)° [ 82.2 (1)° for the disordered chain]. The structure is stabilized by C-H⋯N hydrogen bonds.