نتایج جستجو برای: thr399ile

تعداد نتایج: 111  

Journal: :Memorias do Instituto Oswaldo Cruz 2008
German Zafra Oscar Flórez Carlos A Morillo Luis Eduardo Echeverría Javier Martín Clara Isabel González

The aim of this study was to test the possible implication of toll-like receptor 2 (TLR2) and TLR4 gene polymorphisms in determining the susceptibility to Chagas' disease. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in 475 individuals from Colombia, 143 seropositive with chagasic cardiomyopathy, 132 seropositive asymptomatic and 200 seronegati...

Journal: :European heart journal 2006
Werner Koch Petra Hoppmann Arne Pfeufer Albert Schömig Adnan Kastrati

AIMS The toll-like receptor 4 (TLR4) is predominantly known for its role as an important mediator of immune reactions and has been implicated in the initiation, progression, and plaque destabilization stages of atherosclerosis. We investigated whether genotypes and haplotypes of the 896A/G (Asp299Gly; rs4986790) and 1196C/T (Thr399Ile; rs4986791) single nucleotide polymorphisms of the gene enco...

2013
Homa Davoodi Seyed Reza Hashemi Heng Fong Seow

Two common single nucleotide polymorphisms (SNPs) of the human TLR4 gene, namely Asp299Gly (D299G) and Thr399Ile (T399I), have been shown to impair the ability of certain individuals to respond properly to TLR4 ligands. 5-Fluorouracil (5-FU) is widely used for the treatment of patients with advanced colon cancers. The present study examined the impact of two common polymorphisms of the TLR4 gen...

2012
Eun Jung Kim Woo Chul Chung Kang-Moon Lee Chang Nyol Paik Sung Hoon Jung Bo In Lee Hiun Suk Chae Kyu Yong Choi

The innate immune response in patients who develop inflammatory bowel disease (IBD) may be abnormal. However, the exact role of Toll-like receptors (TLRs) / CD14 gene in the pathogenesis of IBD has not been fully elucidated. We aimed to investigate the association between polymorphisms of TLR1, 2, 4, 6, and CD14 gene and susceptibility to IBD in Korean population. A total 144 patients of IBD (9...

Journal: :Clinical chemistry 2005
Saskia Z H Rittersma Johanna A Kremer Hovinga Karel T Koch S Matthijs Boekholdt Benien E van Aken Arko Scheepmaker Matthijs Bax Carl E Schotborgh Jan J Piek Jan G P Tijssen Pieter H Reitsma Robbert J de Winter

BACKGROUND In coronary in-stent restenosis (ISR), a substantial contribution of inflammation is assumed. We evaluated the association between polymorphisms in the Toll-like receptor 4 (TLR4) gene and cytokine response after lipopolysaccharide (LPS) challenge and the development of ISR. METHODS Patients were included after successful elective stent placement in a native coronary artery and wer...

2016
Gaurav Lachuriya Ravindra Kumar Garg Amita Jain Hardeep Singh Malhotra Arvind Kumar Singh Bhawna Jain Neeraj Kumar Rajesh Verma Praveen Kumar Sharma

We evaluated seizure profile, Toll-like receptor (TLR)-4 polymorphisms, and serum matrix metalloproteinases (MMPs) in patients with calcified neurocysticercosis.One-hundred nine patients with calcified neurocysticercosis with newly diagnosed seizures and 109 control subjects were enrolled. TLR-4 Asp299Gly and Thr399Ile polymorphisms and serum MMP-9 levels were evaluated. The patients were follo...

Two common single nucleotide polymorphisms (SNPs) of the human TLR4 gene, namely Asp299Gly (D299G) and Thr399Ile (T399I), have been shown to impair the ability of certain individuals to respond properly to TLR4 ligands. 5-Fluorouracil (5-FU) is widely used for the treatment of patients with advanced colon cancers. The present study examined the impact of two common polymorphisms of the TLR4 gen...

Two common single nucleotide polymorphisms (SNPs) of the human TLR4 gene, namely Asp299Gly (D299G) and Thr399Ile (T399I), have been shown to impair the ability of certain individuals to respond properly to TLR4 ligands. 5-Fluorouracil (5-FU) is widely used for the treatment of patients with advanced colon cancers. The present study examined the impact of two common polymorphisms of the TLR4 gen...

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