Emergency endarterectomy of an occluded internal carotid artery (ICA) has not been investigated as an option of rescue therapy for severe acute ischemic stroke in the era of intravenous (IV) thrombolysis treatment neither as a primary treatment nor after failed IV thrombolysis. Data from the pre-IV thrombolysis era are conflicting and therefore emergency endarterectomy has not been recommended....

Coronary thrombolysis was induced by infusion of highly purified human pro-urokinase isolated from a transformed kidney cell line (ACHN) or by infusion of urokinase of urinary origin in anesthetized dogs with 1-hr-old clots in the left anterior descending coronary artery. The clots were induced with a copper coil and thrombolysis was detected by repeat coronary angiography. Intravenous infusion...

BACKGROUND Cardiac arrest in patients with pulmonary embolism (PE) is associated with high morbidity and mortality. Thrombolysis is expected to improve the outcome in these patients. However studies evaluating rescue-thrombolysis in patients with PE are missing, mainly due to the difficulties of clinical diagnosis of PE. We aimed to determine the success influencing factors of thrombolysis duri...

Compared to other etiologies of ischemic stroke, occlusive internal carotid artery dissection responds worse to intravenous (IV) thrombolysis. Intracranial tandem occlusion is a predictor of poor outcome. A direct endovascular approach has been proposed as a safe and probably superior alternative to IV thrombolysis. However, it may lead to considerable treatment delays. We used rapidly initiate...

background : immunogenicity of streptokinase (stk), as a thrombolytic drug, have limited its clinical use. elimination of the amino acid residues that are responsible for immunogenicity while don’t affect the bioactivity of stk is worthy. recently, we modified the stk through elimination of 42 amino acids from its’ c-terminal and assessed its bioactivity in vitro . objective : in this study, bi...

ankylosing spondylitis (as) is an inflammatory rheumatic disease. phlegmasia cerulea dolens is a severe form of deep vein thrombosis characterized by swelling, pain, and bluish discoloration. treatment delay may cause venous gangrene, tissue ischemia, limb loss or death. here, we present an as case who presented with phlegmasia cerulea dolens and treated by catheter-directed thrombolysis.

In a prospective study, nine patients with phlegmasia caerulea dolens (PCD) related to iliac occlusive thrombosis were treated with intravenous thrombolysis. After thrombolysis, despite no significant improvement in the Marder score value, progression to venous gangrene, major hemorrhage or death was not observed and no amputation was needed. Intravenous thrombolysis should be seriously conside...

Prosthetic valve thrombosis (PVT) is classically a cardiothoracic surgical emergency. Case series, however, report thrombolysis as first line management for PVT. A case of mitral PVT treated successfully with thrombolysis is described. Immediately after thrombolysis a trivial paraprosthetic leak noted on pretreatment transoesophageal echocardiography had increased significantly in severity. The...

Pregnancy-associated high-risk pulmonary embolism (PE) is among the most frequent causes of maternal mortality in Western world, by causing hemodynamic instability and circulatory failure through a large thrombotic obstruction. The very challenging management these dramatic situations comprises need to quickly select therapy reperfusion or replacement, while taking into account both fetal risks...