OBJECTIVE To examine use of thrombolytic drugs for myocardial infarction and use of contraindications to treatment in the United Kingdom. DESIGN Observational study, based on a continuing audit. SETTING 39 hospitals in the United Kingdom. PATIENTS 30,029 patients admitted between November 1992 and June 1995 with suspected myocardial infarction. RESULTS Of 13,628 patients with a final di...

stroke is an important cause of disability and death worldwide, with the majority of strokes occurring in older people. thrombolysis with recombinant tissue plasminogen activator (r-tpa) is the approved treatment for acute ischemic stroke. a major concern of physicians, who treat acute ischemic stroke with recombinant tissue plasminogen activator (r-tpa,) is the risk of intracerebral hemorrhage...

Background: The brain releases biochemical substrates, such as S100β protein, into circulation in response to ischemic conditions a sign of damage nerve cells and disruption the blood-brain barrier’s integrity. Thrombolytic therapy has led development many neuroprotective therapies phosphatidylcholine, phosphatidylserine, inulin, which can be added food products. Protein, phospholipids, have im...

Objectives: To compare a system of prehospital thrombolytic therapy, delivered by paramedics under medical guidance, with in-hospital thrombolytic therapy in meeting National Service Framework (NSF) targets for treatment of acute myocardial infarction at a District General Hospital setting in England. Design: Retrospective observational case-control study comparing patients with suspected acute...

Successful Treatment of Axillary-Subclavian Artery Thrombosis by Catheter-Based Thrombolytic Therapy: A Case Report

PURPOSE To determine whether subclinical cholesterol embolization is a frequent sequela of thrombolytic therapy. Case reports of catastrophic cholesterol embolization temporally associated with thrombolytic therapy in 19 patients have suggested a causal relationship. PATIENTS AND METHODS We prospectively followed 60 patients with acute myocardial infarction who underwent coronary bypass surge...

BACKGROUND QT dispersion (QTd) is equal to longer QTc minus shorter QTc measured by 12-lead electrocardiogram (ECG). QTd reflects inhomogeneity in repolarization of ventricular myocardium and because of easy and fast measurement of QTd, it can be used to predict high-risk patients for dysrhythmia after Acute Myocardial Infarction (AMI). OBJECTIVES This study aimed to assess the effect of thro...

BACKGROUND Many trials have been done to compare primary percutaneous transluminal coronary angioplasty (PTCA) with thrombolytic therapy for acute ST-segment elevation myocardial infarction (AMI). Our aim was to look at the combined results of these trials and to ascertain which reperfusion therapy is most effective. METHODS We did a search of published work and identified 23 trials, which to...

BACKGROUND AND PURPOSE Blood-brain barrier disruption may be a predictor of hemorrhagic transformation (HT) in ischemic stroke. We hypothesize that parenchymal enhancement (PE) on postcontrast T1-weighted MRI predicts and localizes subsequent HT. METHODS In a prospective study, 33 tPA-treated stroke patients were imaged by perfusion-weighted imaging, T1 and FLAIR before thrombolytic therapy a...

CMAJ • JULY 8, 2003; 169 (1) 35 The care of patients with ST-segment elevation myocardial infarction (STEMI) is continually evolving. In the early 1960s, typical care involved primarily bedrest with few, if any, interventions. This was followed by an era of closer observation in coronary care units but still little in the way of beneficial medical interventions apart from prompt cardioversion o...