T HE PURPOSE of this paper is to report the clinical and pathologic manifestations of seven cases of the platelet thrombosis syndrome. In 1925 Moschowitz' first described a rapidly fatal disease characterized by fever, anemia, petechiae, neurologic signs and autopsy findings of generalized capillary and arteriolar hyaline thrombi. Since then approximately 45 cases have been reported,2-30 most o...

T HE PURPOSE of this paper is to report the clinical and pathologic manifestations of seven cases of the platelet thrombosis syndrome. In 1925 Moschowitz' first described a rapidly fatal disease characterized by fever, anemia, petechiae, neurologic signs and autopsy findings of generalized capillary and arteriolar hyaline thrombi. Since then approximately 45 cases have been reported,2-30 most o...

T HE PURPOSE of this paper is to report the clinical and pathologic manifestations of seven cases of the platelet thrombosis syndrome. In 1925 Moschowitz' first described a rapidly fatal disease characterized by fever, anemia, petechiae, neurologic signs and autopsy findings of generalized capillary and arteriolar hyaline thrombi. Since then approximately 45 cases have been reported,2-30 most o...

Coronary artery disease (CAD) commonly occurs in individuals over the age of 45 years. Several studies categorize “young” with CAD or acute myocardial infarction as those below ages 40 and 45. The protection provided by young has slowly been eroded risk factors like smoking, obesity, sedentary lifestyle that are becoming more common among individuals. We report a case 21-yea...

BACKGROUND A single base pair mutation in the prothrombin gene has recently been identified that is associated with increased prothrombin levels. Whether this mutation increases the risks of arterial and venous thrombosis among healthy individuals is controversial. METHODS AND RESULTS In a prospective cohort of 14 916 men, we determined the prevalence of the G20210A prothrombin gene variant i...

Thrombosis occurs most often as myocardial infarction, cerebral infarction or venous thromboembolism, ie, deep-vein thrombosis and pulmonary embolism. The incidence of all types of thrombosis is strongly dependent on age. Among young individuals, up to age 40, venous thrombosis is the most common form of thrombosis. The risk factors for arterial and venous thrombosis differ, and among the latte...

Thrombotic thrombocytopenic purpura (TTP) is a rare variant of thrombotic microangiopathy. We report case TTP in Nigerian chronic kidney disease (CKD) patient who was previously on clopidogrel. The features resolved soon after clopidogrel withdrawn. Clopidogrel cardio-protective anti-platelet drug used CKD patients at risk dyspepsia. However, its potential to cause should be recognized and cons...

Prosthetic valve thrombosis (PVT) is a rare and fatal complication requiring immediate treatment. Optimal management of the left-sided obstructive PVT is still controversial and depends on patient's status, estimated risk of surgery, thrombus location and size, and clinician's experience. We report a case of a 71-year-old woman, presenting with signs of cardiogenic shock. Transesophageal echosc...

Protein C deficiency is a risk of venous thrombosis because of poor fibrinolytic activity. It remains controversial whether protein C deficiency causes arterial thrombosis. A 21-year-old woman was referred with a chief complaint of right leg pain and numbness. Contrast-enhanced computed tomography revealed a low-density mass in the left ventricle (LV), splenic infarction, and peripheral arteria...

BACKGROUND Great advances have been made in the prevention of thrombotic disorders by developments of new pharmacological and surgical treatments. Animal models of arterial thrombosis have largely contributed to the discovery and to the validation of original treatments. The purpose of the present work was to develop and validate an original model of acute myocardial infarction provoked in pig ...