The transcription of the human UCP3 (uncoupling protein-3) gene in skeletal muscle is tightly regulated by metabolic signals related to fatty acid availability. However, changes in thyroid status also modulate UCP3 gene expression, albeit by unknown mechanisms. We created transgenic mice bearing the entire human UCP3 gene to investigate the effect of thyroid hormones on human UCP3 gene expressi...

Interactions between cytokines and others soluble factors (hormones, antibodies...) can play an important role in the development of thyroid pathogenesis. The purpose of the present study was to examine the possible correlation between serum cytokine concentrations, thyroid hormones (FT4 and TSH) and auto-antibodies (Tg and TPO), and their usefulness in discriminating between different thyroid ...

during the islamic lunar month of ramadan millions of muslims abstain from drinking and eating from dawn to sunset. the objective of this study was to investigate the effect of intermittent islamic fasting on reproductive function, hypothalamic-pituitary-thyroid axis and the peripheral metabolism of thyroid hormones in men. we measured serum levels of fsh, lh, testosterone, prolactin, tsh, t4, ...

Thyroid hormones play a very important role regulating metabolism, development, protein synthesis, and influencing other hormone functions. The two main hormones produced by the thyroid are triiodothyronine (T3) and thyroxine (T4). These hormones can also have significant impact on kidney disease so it is important to consider the physiological association of thyroid dysfunction in relation to ...

An extensive review article on thyroid hormone published nearly 40 years ago (Barker, 1951) might have led one to suppose that little could be added to the subject of thyroid hormones and thermogenesis. However, a large number of new ideas have since emerged with respect to the mechanisms of action of thyroid hormones, although there is still considerable uncertainty as to how they function at ...

introduction: previous studies have shown that ghrelin inhibits the activity of hypothalamus –pituitary – thyroid (h–p-t) axis. it is also proved that ghrelin increases appetite via agouti related protein and neuropeptide y pathway, decreases t3 & t4 secretion and inhibits serotonin release from hypothalamic synaptosomes. serotonin may interact with ghrelin in control of thyroid hormones secret...

The human body is composed of many systems and organs that work together to ensure our well-being survival. Hormones are the messengers allow communicate. thyroid a butterfly-shaped gland located in neck uses iodine from diet (mainly present seafood) produce hormones: thyroxine (T4) triiodothyronine (T3). hormones very important for brain development, growth, metabolism. A lack impairs producti...