INTRODUCTION In normal conditions follicle-stimulating hormone receptors (FSHR) are expressed in the ovary and the testis. They can also be expressed in gonadal tumors. However, recently we have found FSHR immunostaining in pituitary adenomas, adrenal tumors and neuroendocrine tumors (carcinoids). The aim of this study was to determine whether the same occurs in thyroid tumors. MATERIAL AND M...

Monitoring of air and milk samples is done routinely around nuclear facilities that release iodine-131 to the environment. Results from these measurements are used to calculate dose rates to the thyroids of people who live near such facilities. These calculated dose rates have large uncertainty factors associated with them due to the complexity of predicting the movement of iodine-131 through t...

BACKGROUND P53 isoforms originate from the alternative initiation of P53 gene translation through usage of an internal promoter located in intron 4. All P53 isoforms are spliced in intron 9 and may modulate cell proliferation and cell fate outcome in response to DNA damage. AIM To examine immunoexpression of P53 isoforms in benign proliferative lesions occurring in multinodular thyroids and t...

Our previous studies have shown that maternal high estradiol (E2) environment increased the risk of thyroid dysfunction in offspring. However, the mechanism involved remains unexplored. To evaluate the thyroid function of offspring after high E2 exposure and to explore the underlying mechanism, we established a high E2 mouse model of early pregnancy, and detected thyroid hormones of their offsp...

The generation of Abs recognizing the native structure of the human thyrotropin receptor (hTSHR) has been difficult because there is currently no method allowing the purification of correctly folded Ag in the amounts required by classical immunization protocols. The majority of Abs made against the hTSHR react preferentially with denatured molecules. We report that a humoral response against th...

Effect of excessive ingestion of manganese (Mn) on the mouse thyroid was assessed under the conditions of normal intake of iodide. Female mouse thyroids were enlarged after 7 weeks of administration of 200 mg/l MnCl2 X 4H2O in drinking water; 2.74 +/- 0.25 mg for control (N = 56), and 3.31 +/- 0.28 mg for Mn-treated group (N = 85) (p less than 0.001). In contrast, male mouse thyroids never beca...

BACKGROUND Historically, a high percentage of endocrine surgical procedures are performed by general surgeons in nonteaching environments. With the institution of accredited fellowships, we sought to determine whether that dynamic is changing. MATERIALS AND METHODS The American College of Surgeons-National Surgeons Quality Improvement Program was queried for all thyroid, parathyroid, and adre...

The degree of radiation exposure to the thyroids of children who originally lived in Chernobyl contaminated areas is of concern in Israel, because of the many immigrants who arrived from such areas in a wave of immigration from the CIS countries since 1990. Of the 650,000 people who emigrated to Israel since that time, our estimate is that about 20% came from regions of the Ukraine, Russia and ...

Iodine-129 is routinely released in the gaseous and liquid low-level radioactive effluents of nuclear spent fuel reprocessing plants. Environmental impact assessment of these discharges are performed based on monitoring samples of different types of natural indicators. Thyroid is considered as a relevant organ to monitor radioactive iodine isotopes. In this study, bovine thyroids were collected...

Glycans containing α-L-fucose participate in diverse interactions between cells and extracellular matrix. High glycan expression on cell surface is often associated with neoplastic progression. The lysosomal exoenzyme, α-L-fucosidase-1 (FUCA-1) removes fucose residues from glycans. The FUCA-1 gene is down-regulated in highly aggressive and metastatic human tumors. However, the role of FUCA-1 in...