A chemiluminescent labeled-antibody immunoassay has been developed for measurement of total thyroxin (T4) in serum. Monoclonal antibodies to T4 labeled with a chemiluminescent acridinium ester are used. Serum samples are incubated with the labeled antibodies and a thyroxin-rabbit immunoglobulin conjugate, then reacted with magnetizable particles containing sheep anti-rabbit immunoglobulin. The ...

A 63 years old woman with Hashimoto's thyroiditis, on thyroxin treatment presented imaging studies concordant with a multinodular goiter, a "hot" nodule in the left lobe and partial suppression of the right lobe. After thyroxin withdrawal overt hypothyroidism developed, yet the patient's imaging studies were not altered. This is a case of hypothyroidism in a patient with Hashimoto's thyroiditi...

We studied the dependence of the free thyroxin (T4) index and the ratio of T4 to thyroxin-binding globulin (TBG) on TBG concentrations, using sera from cases of congenital TBG deficiency and congenital TBG excess. Two such sera with similar concentrations of albumin, transthyretin, and free T4 were mixed to provide test samples with TBG concentrations covering the range of clinical interest wit...

background: to investigate thyroid function in preeclamptic patients in comparison with normal pregnant women. methods: in this analytical cross-sectional study free thyroxine (t4), and thyroid stimulating hormone (tsh) levels were measured in 100 preeclamptic patients and were compared with free t4 and tsh levels in 101 normal pregnant women in their third trimester of pregnancy. patients with...

OBJECTIVES This study is intended to examine the effect of hypothyroidism and thyroxin replacement on axial and appendicular skeletal growth, growth plate thickness and to observe associated microscopic changes within the growth plates. METHODOLOGY Experimental albino rats were developed with carbimazole and carbimazole plus thyroxin. Animals were administered with these drugs throughout preg...

DRIED THYROID SUBSTANCE or the pure natural hormoue s, L-thyroxin and L-triiodothyronine, effect a reduction in the serum total cholesterol of euthyroid individuals when administered in sufficient allmount.1-3 Their general clinical use to reduce elevated serum cholesterol levels in the hope of favorably influencing the course of atherosclerosis has been limited by two factors. When given in mo...