BACKGROUND Sulfotransferases are present in normal and cancerous human breast tissues. The purpose of this article is to present a hypothetical correlation of sulfotransferase activity with proliferation in breast cancer. MATERIALS AND METHODS Sulfotransferases were evaluated in breast cancer cells by determining the transformation of non-conjugated estrogens to the sulfates. Proliferation wa...

To examine the relationships between serum leptin and bone metabolism, we measured bone mineral density (BMD) at the spine and the hip, fasting serum leptin, and osteocalcin and urinary excretion of C-terminal crosslinking telopeptide of type I collagen (CTX), as markers of bone formation and resorption, respectively, in 121 postmenopausal women aged 54 +/- 5 years. These parameters were also a...

n engl j med 359;20 www.nejm.org november 13, 2008 2172 moderately obese subjects in our study was identical to that reported in a recent meta-analysis on long-term pharmacotherapy for obesity.2 In response to Ornish’s letter: the low-carbohydrate diet was based on Atkins’s book, although we encouraged the study participants to consume a variety of protein and fat sources to maintain successful...

Traumatic brain injury (TBI) is characterized by a complex network of signals mediating inflammatory, proliferative and apoptotic processes during its acute chronic phases. Current therapies mitigate damage are mainly for palliative care there currently no effective secondary damage. This suggests need to discover compound with greater spectrum action that can control various pathological aspec...