The local mechanical environment is a crucial factor in determining cell and tissue differentiation during vertebrate skeletal development and repair. Unlike the basic response of bone to mechanical load, as described in Wolff's law, the mechanobiological relationship between the local mechanical environment and tissue differentiation influences everything from tissue type and molecular archite...

background: development of tissue engineering and regenerative medicine has led to designing scaffolds and their modification to provide a better microenvironment which mimics the natural niche of the cells. gelatin surface modification was applied to improve scaffold flexibility and cytocompatibility. methods: plla/pcl aligned fibrous scaffold was fabricated using electrospinning method. adscs...

Development of engineered tissue scaffolds with superior control over cell-protein interactions is still very much infancy. Advancing through heterogeneous multifold scaffolds with controlled release fashion enables synchronization of regenerating tissue with the release kinetics of loaded biomolecules. This might be an engineering challenge and promising approach for improved and efficient tis...

Tissue regeneration and maintenance rely on coordinated stem cell behaviors. This orchestration can be impaired by oncogenic mutations leading to tissue architecture disruption ultimately cancer formation. However, it is still largely unclear how oncogenes perturb cells’ functions break architecture. Here, we utilized intravital imaging novel signaling reporter investigate the mechanisms of Kra...

this study evaluates the lifelikeness layers of boroujerdi’s house in kashan as a case study to analyze the houses of islamic period, especially qajar era. why traditional iranian architecture was considered as sustainable architecture? what are the elements included in the traditional architecture to take the most advantage of the least facilities? what elements does the modern architecture la...

Introduction: Brain tumors such as glioma are among the most aggressive lesions, which result in a very short life expectancy in patients. Image segmentation is highly essential in medical image analysis with applications, particularly in clinical practices to treat brain tumors. Accurate segmentation of magnetic resonance data is crucial for diagnostic purposes, planning surgical treatments, a...