Background-Histologic grading has been used as a prognostic factor and for clinical behavior evaluation of oral squamous cell carcinoma (SCC) for the past several decades. At the same time, the prognostic value of different grading classifications remains controversial. Methods-A retrospective study of 48 cases of tongue SCC was undertaken to compare different grading systems and their relation...

BACKGROUND The purpose of this study was to evaluate the clinical usefulness of the immunoexpression of Ki-67, matrix metalloproteinase (MMP)-2, MMP-9, vascular endothelial growth factor (VEGF)-C, and VEGF-D in predicting follow-up treatment in patients with squamous cell carcinoma (SCC) of the tongue and floor of the mouth (FOM). METHODS Marker expression was evaluated in surgical specimens ...

BACKGROUND/AIM This study aimed to examine the demographics and histopathological features of oral cavity cancers (OCCs) managed in our clinic. MATERIALS AND METHODS Patients who were diagnosed with OCCs in the Gazi University Otorhinolaryngology Department between the years 1993 and 2013 were retrospectively enrolled in the study. Surgical archive charts and pathology records were reviewed i...

Enamel matrix derivative (EMD) can mimic odontogenic effects by inducing the proliferation and differentiation of connective tissue progenitor cells, stimulating bone growth and arresting epithelial cells migration. To the best of our knowledge, there is no data indicating that any active component of EMD reduces epithelial cell viability. The present study examines the impact of commercial lyo...

BACKGROUND Sclerotherapy is a common and effective treatment for venous diseases, including venous malformations (VMs), which are common vascular anomalies in the oral and maxillofacial regions. However, the safety of sclerotherapy has not been fully elucidated. Occasionally, patients who underwent sclerotherapy may present diverse but minor side effects such as erythema, swelling, pain, tender...

OBJECTIVES This study analyzed various clinical and histopathologic factors for patients with early stage squamous cell carcinoma (SCC) of the oral tongue to define a high risk group for regional recurrence and finally to find out the indication of elective neck dissection (END). METHODS Retrospective chart review was performed for 63 patients with T1-T2N0 SCC of the oral tongue who underwent...

Fatty acid synthase (FASN) is the biosynthetic enzyme responsible for the endogenous synthesis of fatty acids. It is downregulated in most normal cells, except in lipogenic tissues such as liver, lactating breast, fetal lung, and adipose tissue. Conversely, several human cancers, including head and neck squamous cell carcinomas (HNSCC), overexpress FASN, which has been associated with poor prog...

Head and neck squamous cell carcinoma (HNSCC) which includes the oral cavity, oropharynx and larynx is the sixth most common cancer worldwide with an estimated 633,000 incident cases and 335,000 deaths annually[1,2]. Human papillomavirus (HPV) is specifically associated with squamous cell carcinomas (SCC) of the oropharynx which encompasses the base of the tongue, lingual and palatine tonsils a...