Adult and pediatric patients (n = 347) with atopic dermatitis enrolled in three multicenter, randomized, 6-week studies who had previously used steroids were analyzed to examine the null hypothesis that improvement in atopic dermatitis initiated after prior treatment with steroids eliminates any subsequent treatment differences between tacrolimus ointment and pimecrolimus cream. Of these patien...

In order to improve local therapeutic techniques for the massively burnt patients and to minimize the pain associated with dressing change, the concept of topical film was utilized to formulate a topical antimicrobial spray. The commonly used topical antimicrobial silver sulfadiazine spray was formulated as a new drug delivery system. The release of therapeutic agents in vitro from medicated sp...

A 69-year-old non-atopic woman presented with eczematous lesions on her legs, trunk, and upper limbs. The history revealed that, one month before the development of the eczema, she had been applying an emollient cream to her legs (BioEulen Pediatric Cream, Aboca, Sansepolcro, Italy) based on natural ingredients to treat a moderate xerosis. She was treated with topical corticosteroids (mometason...

BACKGROUND Treatment of melasma is unsatisfactory most of the times. Hormonal role is shown to exist in pathogenesis of the melasma, and sex-hormone related drugs may have an effect on melasma. AIM To investigate efficacy of 1% flutamide cream versus 4% hydroquinone cream on melasma. METHODS In a parallel randomized clinical trial, 74 women with melasma were allocated to receive a sunscreen...

OBJECTIVE To investigate the effect of capsaicin cream on the secretion of the submandibular gland (SMG) and the parotid gland (PG) in the general population, with different chilli-eating habits. METHODS In two groups with different chilli-eating habits, the salivary flow rate of the SMG and the PG was detected at statics and different times, after application of capsaicin cream. RESULTS In...

The macrocycle family of molecules called cucurbit[n]urils are potential drug delivery vehicles as they are able to form host-guest complexes with many different classes of drugs. This study aimed to examine the utility of Cucurbit[6]uril (CB[6]) in topical cream-based formulations for either localised treatment or for transdermal delivery. Cucurbit[6]uril was formulated into both buffered crea...

Three percent 5-ethyl-2'-deoxyuridine (EdU) in an aqueous cream base was compared with 5% acyclovir (ACV) in polyethylene glycol ointment and 3% EdU in 95% dimethyl sulfoxide (DMSO) for efficacy in the topical treatment of an experimental dorsal cutaneous herpes simplex virus type 1 infection in guinea pigs. Topical ACV treatment reduced the mean lesion number by 15%, the lesion area by 32%, an...

Although TGs have been shown to be efficient in treatment of various skin diseases, their use can result in both local and systemic side effects. Some of the local side effects are skin atrophy, rosacea, and corticoid acne, while the major systemic side effects are hypothalamic-pituitary-adrenal-axis suppression along with diabetes mellitus and hypertension [1,7-9]. Mometasone furoate (MF) is a...

BACKGROUND Pain is a common adverse effect of dermatological laser procedures. Currently, no standard topical anaesthetic cream exists for deeper dermal laser procedures. OBJECTIVES To compare the efficacy of lidocaine/tetracaine cream and lidocaine/prilocaine cream in reducing self-reported pain during deeper dermal laser treatment of acne keloidalis nuchae (AKN) and tattoos. METHODS We co...

Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit. The role of Pityrosporum ovale (P.ovale) in the exacerbation of acne is still under debate. Objective: To determine the efficacy of topical 2% ketoconazole cream in comparison to placebo in the treatment of acne vulgaris in patients with positive smear for P.ovale. Patients and Methods: A smear was obtained from ...