A new total synthesis of the alkaloid variolin B is achieved by a selective and sequential palladium-mediated functionalization of a trihalo-substituted pyrido[30,20:4,5]pyrrolo[1,2-c]pyrimidine. This intermediate is obtained by a new heterocyclization reaction between an appropriate bromomethyl azaindole and N-tosylmethyl dichloroformimide. The methodology may be effective for the synthesis of...

The structure previously assigned to the phenolic noraporphine alkaloid, (-)-norannuradhapurine has been confirmed by a total synthesis of the racemic alkaloid in which the key step involved the formation of the C ring by a radical-initiated cyclization. although inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028, (+/-)-norannuradhapurine...

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OBJECTIVES Belonging to Papaveraceae family, Glaucium vitellinum is one of the Persian endemic plants which has not been investigated biologically. The present paper focused on the assessment of the antibacterial and antifungal activities of the total methanol extract and alkaloid sub-fraction of the flowering aerial parts of G. vitellinum. MATERIALS AND METHODS The antibacterial and antifung...

In the present investigation Catharanthus roseus, an important herb used in traditional as well as modern medicine, exposed to water deficit stress and possible changes in chlorophyll contents, photosynthesis rate, transpiration rate, growth parameters as well as total alkaloid content and vincristine and vinblastine levels were studied. Seedlings subjected to 4 different water-regimes. Experim...

The phenolic composition of extracts from Uncaria tomentosa L. from different regions of Costa Rica was studied using advanced analytical techniques such as UPLC/TQ-ESI-MS and (13)C-NMR. Samples from leaves, stems, bark and wood (n = 22) were subjected to extraction to obtain phenolic and alkaloid extracts, separately. Comparatively, higher values of total phenolic content were observed for lea...

Background: Numerous molecules in Papaveraceae family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. Objective: Numerous molecules in this family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few...

hydroalcoholic extract of pycnocycla spinosa was shown to have spasmolytic action in vitro and antidiarrhoeal effect in vivo . the hydroalcoholic extract of p. spinosa is composed of alkaloid, flavonoid and saponin components. alkaloid fraction of p. spinosa contains the most active constituents. therefore, the aim of this research was to separate different fractions of alkaloid extract of p. s...