OBJECTIVE To evaluate the benefits of using serial measurements of plasma cholinesterase (butyrylcholinesterase, BuChE) activity in the management of cholinesterase inhibitor insecticidal poisoning. METHOD After establishing and validating BuChE activity test, and making it available for clinical service in the toxicology laboratory at Jordan University Hospital. Serial measurements of BuChE ...

Spice is an herbal mixture smoked for euphoria and mixed with synthetic cannabinoids that are undetected on urine drug screens. Spice use has increased in the military because it is considered legal and is not detected on urine drug screen. The authors describe 3 cases of Spice use in military members. Case 1: 19-year-old male presented with paranoia, agitation, and visual hallucinations after ...

Mining chemical compounds in silico has drawn increasing attention from both academia and pharmaceutical industry due to its effectiveness in aiding the drug discovery process. Since graphs are the natural representation for chemical compounds, most of the mining algorithms focus on mining chemical graphs. Chemical graph mining approaches have many applications in the drug discovery process tha...

Automatic monitoring of the concentration of test gases and other environmental variables in small animal inhalation exposure chambers, coupled with computing capability and feedback control of the concentration of test gas, allows almost fully automatic operation of the chambers with a minimal amount of human intervention. Time-varying exposure profiles may be generated repeatedly with great a...

This edition rapidly follows the revised edition by John Glaister, both books being the products of the Scottish school, which, of late years, has done so much to keep British forensic medicine in the front rank. The author has brought up to date the changes in the Poison and Pharmacy Act as well as the list of industrial diseases under the Factories Act and the Workmen's Compensation Act. Ever...

The identification of general unknown poisons in complex biological materials like postmortem blood and tissue is a great challenge for the forensic toxicologist. Therefore, a screening procedure utilizing a semi-automatic work-up with an ASPEC system was developed. A broad range of different compounds can be isolated by using non-selective and generally applicable organic polymeric sorbents su...

The incidence and range of spontaneous central nervous system tumors were determined in control Charles River rodents (Sprague-Dawley, Han-Wistar, Wistar rats, and CD-1 mice) from regulatory carcinogenicity studies carried out over the period 2002 to 2013 and were compared with the previously published data. In both species, the brain was notably more affected than the spinal cord. Incidences w...

INTRODUCTION Public concern about adverse health effects from mercury exposure from dental amalgams remains a high-profile issue. Patients with nonspecific neuropsychiatric symptoms may incorrectly attribute their complaints to mercury poisoning, and some alternative medical providers diagnose mercury toxicity using nonvalidated tests or without testing at all. CASE REPORT We report the case ...

The lung is the primary organ likely to be exposed by inhalation studies and, therefore, measurement of changes in lung function are of particular interest to the pulmonary physiologist and toxicologist. Tests of pulmonary function have been developed which can be used with small animals to measure spirometry (lung volumes), mechanics, distribution of ventilation, gas exchange or control of ven...

The prospect of bearing an abnormal or deformed child has long been a chilling fear of all expectant mothers. Of the estimated 130 million children born each year worldwide, ] at least 2 to 3 percent are born with some type of birth defect.z It has only been within the last 150 years that doctors have attempted to interpret birth defects, or congenital malformations, in a scientific manner. The...