Quantitative structure-toxicity relationships were developed for the prediction of aqueous toxicities for Poecilia reticulata (guppy) using the CODESSA treatment. A two-parameter correlation was found for class 1 toxins with R(2) = 0.96, and a five-parameter correlation was found for class 2 toxins with R(2) = 0.92. A five-parameter correlation for class 3 toxins had R(2) = 0.85. The correlatio...

The impact of toxins on the developing brain is usually subtle for an individual child, but the damage can be substantial at the population level. Numerous challenges must be addressed to definitively test the impact of toxins on brain development in children: We must quantify exposure using a biologic marker or pollutant; account for an ever-expanding set of potential confounders; identify cri...

Two toxins, designated Hemachatus haemachatus toxins II and IV, have been isolated from the venom of the South African Ringhals (H. haemachatus) by gradient chromatography on A.mberlite CG-50, and have been further purified by gel filtration on Sephadex G-50. The toxins are essentially homogeneous by free boundary electrophoresis, ultracentrifugation, and amino acid analyses. Toxins II and IV h...

Pet birds, being previously unexposed to the many dangers of our industrial world, are prime candidates for the ingestion/inhalation of toxins. What follows is a highlight of the most common toxins found in our homes. These will include "acute" fast acting fatal toxins and the "chronic" more long term, but still deadly types of toxins. REMEMBER: WHEN CONSIDERING IF A PRODUCT MIGHT BE TOXIC OR N...

Snake curaremimetic toxins are currently classified as short-chain and long-chain toxins according to their size and their number of disulfide bonds. All these toxins bind with high affinity to muscular-type nicotinic acetylcholine receptor, whereas only long toxins recognize the alpha7 receptor with high affinity. On the basis of binding experiments with Torpedo or neuronal alpha7 receptors us...

clostridium difficile is the most common cause of nosocomial diarrhea. it is usually a consequence of antibiotic treatment, but sporadic cases can occur. this study was aimed to determine the frequency of the nosocomial clostridium difficile (c. difficile) associated diarrhea in tehran university of medical sciences hospitals and study of antibacterial susceptibility of isolates. in this study ...