نتایج جستجو برای: tp53 mutation and expression

تعداد نتایج: 16973495  

2016
Sungjin Park Jinhyuk Lee Yon Hui Kim Jaheun Park Jung-Woog Shin Seungyoon Nam

While altered TP53 is the most frequent mutation in gastric cancer (GC), its association with molecular or clinical phenotypes (e.g., overall survival, disease-free survival) remains little known. To that end, we can use genome-wide approaches to identify altered genes significantly related to mutated TP53. Here, we identified significant differences in clinical outcomes, as well as in molecula...

2018
Michaela Angelika Ihle Sebastian Huss Wiebke Jeske Wolfgang Hartmann Sabine Merkelbach-Bruse Hans-Ulrich Schildhaus Reinhard Büttner Harri Sihto Kirsten Sundby Hall Mikael Eriksson Peter Reichardt Heikki Joensuu Eva Wardelmann

Despite of multitude investigations no reliable prognostic immunohistochemical biomarkers in GIST have been established so far with added value to predict the recurrence risk of high risk GIST besides mitotic count, primary location and size. In this study, we analyzed the prognostic relevance of eight cell cycle and apoptosis modulators and of TP53 mutations for prognosis in GIST with high ris...

2009
André S Khayat Adriana C Guimarães Danielle Q Calcagno Aline D Seabra Eleonidas M Lima Mariana F Leal Mário HG Faria Silvia HB Rabenhorst Paulo P Assumpção Samia Demachki Marília AC Smith Rommel R Burbano

BACKGROUND This study evaluates the existence of numerical alterations of chromosome 17 and TP53 gene deletion in gastric adenocarcinoma. The p53 protein expression was also evaluated, as well as, possible associations with clinicopathological characteristics. METHODS Dual-color fluorescence in situ hybridization and immunostaining were performed in twenty gastric cancer samples of individual...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Els M J J Berns Jan G M Klijn Maxime P Look Nicolai Grebenchtchikov Rolf Vossen Harry Peters Anneke Geurts-Moespot Henk Portengen Iris L van Staveren Marion E Meijer-van Gelder Bert Bakker Fred C G J Sweep John A Foekens

PURPOSE In recent studies, we showed that TP53 gene mutation or high levels of cytosolic vascular endothelial growth factor (VEGF) in estrogen receptor (ER)-alpha-positive primary breast tumors predict a poor disease outcome for patients treated with first-line tamoxifen for advanced disease. Mutant TP53 may up-regulate VEGF, whereas, on the other hand, wild-type TP53 may decrease VEGF producti...

2018
A-Jian Li Hua-Guang Li Er-Jiang Tang Wei Wu Ying Chen Hui-Hong Jiang Mou-Bin Lin Lu Yin

AIM To investigate the predictive value of PIK3CA and TP53 mutation status in colorectal cancer (CRC) patients treated with 5-fluorouracil-based chemotherapy. METHODS In this study, a total of 315 patients with histologically proven CRC were enrolled from Yangpu Hospital affiliated to Shanghai Tongji University between 2007 and 2011. Of these patients, 241 with stage II/III CRC received 5-flu...

2014
Mitsugu Yamamoto Mitsuchika Hosoda Kiichiroh Nakano Shusheng Jia Kanako C Hatanaka Emi Takakuwa Yutaka Hatanaka Yoshihiro Matsuno Hiroko Yamashita

Aromatase inhibitors have played a central role in endocrine therapy for estrogen receptor (ER)-positive breast cancer in postmenopausal women. However, factors predictive of the efficacy of aromatase inhibitors, and prognostic factors, both for early and late recurrence in women treated with adjuvant aromatase inhibitors have not been identified. Whole genome analysis identified that a TP53 ge...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Rossella Libè Lionel Groussin Frédérique Tissier Caroline Elie Fernande René-Corail Amato Fratticci Eric Jullian Paolo Beck-Peccoz Xavier Bertagna Christine Gicquel Jérôme Bertherat

PURPOSE Allelic losses [loss of heterozygosity (LOH)] at the 17p13 locus are frequent (85%) in adrenocortical cancers. The tumor suppressor gene TP53 is located at 17p13. The aim of the study was to determine the frequency of TP53 somatic inactivating mutations in adrenocortical tumors with 17p13 LOH and their clinico-biological correlations. EXPERIMENTAL DESIGN TP53 somatic mutations, intrag...

Journal: :iranian journal of basic medical sciences 0
azadeh lohrasbi nejad department of biotechnology, research institute for environmental sciences, international centre for science, high technology and environmental sciences, kerman, iran mohammad mehdi yaghoobi department of biotechnology, research institute for environmental sciences, international centre for science, high technology and environmental sciences, kerman, iran

objective(s) p53 is an important tumor suppressor, which is mutated in later stages of many cancers and leads to resistance to chemotherapy. the aim of this study was to reveal mutations of tp53 in colorectal cancer in kerman province. materials and methods a total of forty-three colon cancer specimens as paraffin block or fresh tissues, which passed stage iiia, were selected. three exons 5, 7 ...

2010
Ahmed Ashour Ahmed Dariush Etemadmoghadam Jillian Temple Andy G Lynch Mohamed Riad Raghwa Sharma Colin Stewart Sian Fereday Carlos Caldas Anna deFazio David Bowtell James D Brenton

Numerous studies have tested the association between TP53 mutations in ovarian cancer and prognosis but these have been consistently confounded by limitations in study design, methodology, and/or heterogeneity in the sample cohort. High-grade serous (HGS) carcinoma is the most clinically important histological subtype of ovarian cancer. As these tumours may arise from the ovary, Fallopian tube ...

Journal: :Human mutation 2003
Kirsi Vähäkangas

In some cases, evidence exists that exogenous carcinogenic exposures contribute to the mutation spectrum of the TP53 gene (p53) in human cancers. Although the clearest examples come from dietary and environmental sources, only a restricted number of papers have concentrated specifically on TP53 mutations in tumors from workers exposed to occupational carcinogens. In populations exposed to dieta...

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