BACKGROUND & AIMS Our previous studies have provided evidence that p38 mitogen-activated protein kinase (MAPK) is involved in total parenteral nutrition (TPN)-associated complications, but its exact effects and mechanisms have not been fully understood. This study aimed to evaluate the roles of p38 MAPK inhibitor SB203580 in the TPN-induced loss of intestinal barrier function and liver disease....

BACKGROUND Enteral nutrition (EN) is now used more frequently than total parenteral nutrition (TPN) for nutritional support after resection for esophageal cancer. But consensus regarding which type of nutrition should be used does not exist. We studied the effect of TPN and EN on patients' nutritional status and immune function in the immediate postoperative period after esophageal cancer resec...

This paper presents Timed Petri Nets (TPN) as an analytical approach for verification of computerized queueing network simulation models at steady state. It introduces a generic approach to decomposing a queueing network into separate and independent TPNs, each representing a resource of specific type, such as a processing resource or a transporting resource. A decomposed TPN model enables a qu...

BACKGROUND This prospective study was designed to compare the safety, efficacy, cost, and impact on patient outcome of early total enteral nutrition (TEN) vs total parenteral nutrition (TPN) in acute pancreatitis. METHODS Patients admitted with acute pancreatitis or an acute flare of chronic pancreatitis, characterized by abdominal pain and elevated serum amylase and lipase, were randomized t...

HYPOTHESIS Intravenous total parenteral nutrition (TPN) induces intestinal polymorphonuclear neutrophil recruitment with increased intestinal intercellular adhesion molecule-1 expression. While intercellular adhesion molecule-1 causes firm adhesion of leukocytes to the endothelial cells, P- and E-selectin mediate leukocyte recruitment via rolling. Therefore, manipulation of nutrition may also a...

BACKGROUND New national guidelines recommend more restricted fluid intake and early initiation of total parenteral nutrition (TPN) in very preterm infants. The aim was study the effect of these guidelines on serum sodium and potassium levels and fluid balance in the first three days after birth. METHODS Two cohorts of infants <28 weeks gestational age, born at the Leiden University Medical Ce...

Although standard supportive care for bone marrow transplant (BMT) recipients includes total parenteral nutrition (TPN), it has not been shown that this is the most appropriate method of nutritional support. To determine whether current BMT recipients require TPN during the early recovery period, we conducted a prospective, randomized clinical trial comparing TPN and an individualized enterai f...

The article in this issue by Dimick et al 1 about total parenteral nutrition (TPN) and infections associated with use of central venous catheters addresses a major concern in critical care medicine. In day-to-day practice, certain intervention-related complications are inevitable. As our understanding in general improves, we find many other factors that contribute to complications. Dimick et al...

Let k an algebraically closed field, P the n-dimensional projective space over k and TPn the tangent vector bundle of P . In this paper I prove the following result : for every integer l, for every non-negative integer s, if Zs is the union of s points in sufficiently general position in P, then the restriction map H(P, TPn(l)) → H 0(Zs, TPn(l)|Zs) has maximal rank. This result implies that the...

INTRODUCTION A preliminary one-year review of total parenteral nutrition (TPN) in the adult surgical intensive care unit (SICU) in view of its complications, cost and lack of consistent benefits in the critically ill. MATERIALS AND METHODS All the case records of patients receiving TPN in the SICU starting from first January to end December 1998 were studied. RESULTS Fifty patients received...