نتایج جستجو برای: traf1
تعداد نتایج: 238 فیلتر نتایج به سال:
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues. Although some genetic risk factors for RA are well-established, most notably HLA-DRB1 and PTPN22, these markers do not fully account for the observed heritability. To identify additional susceptibility loci, we carried out a multi-tiered, case-control association study, genotyp...
INTRODUCTION Both genetic and environmental factors contribute to rheumatoid arthritis (RA), a common and complex autoimmune disease. As well as the major susceptibility gene HLA-DRB1, recent genome-wide and candidate-gene studies reported additional evidence for association of single nucleotide polymorphism (SNP) markers in the PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5 loci with RA. This study...
Juvenile idiopathic arthritis (JIA) is the most frequent rheumatic disease in children and could lead to severe disability. The aim of this study was to determine the role of gene polymorphisms in predicting the clinical response of anti-TNF therapy in JIA patients. 68 patients with JIA and 20 healthy controls (HC) were included in the study, and patients with JIA received anti-TNF treatment fo...
Treatment of highly tumorigenic MDA-MB-231 human breast cancer cells with indole-3-carbinol (I3C) directly inhibited the extracellular elastase-dependent cleavage of membrane-associated CD40, a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 signaling has been implicated in regulating cell survival, apoptosis, and proliferation, as well as in sensitizing breast cancer cells...
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