BACKGROUND Primary liver tumours (PLTs) are currently a major health problem worldwide. The study's aim was to investigate the feasibility, toxicity, and activity of hepatic intra-arterial chemotherapy (HIAC) in patients with advanced PLTs. METHODS We retrospectively analysed 43 patients with advanced unresectable PLT, who were consecutively treated. HIAC with 5-fluorouracil, cisplatin, and m...

Herpes hepatitis is a rare cause of fulminant hepatic failure contributing to less than 1% of all cases. It is most often seen in persons who are immunosuppressed and in pregnant women. The presentation is usually non-specific and rapidly progressive, thus making antemortem diagnosis of this condition rare. We present a patient who was on chronic immunosuppressive therapy for systemic lupus ery...

Acute HIV and acute hepatitis B coinfection is extremely rare. A 23-year-old homosexual man was admitted to our hospital with 5-day history of fever, malaise, and back pain with initial laboratory values showing severe transaminitis. The clinical picture was initially suggestive of acute viral hepatitis, which on further testing revealed acute hepatitis B and acute HIV coinfection. Although the...

Acute infection with human immunodeficiency virus (HIV) is infrequently diagnosed, owing in large part to vague or non-specific symptoms. Among the most common of these symptoms are fever, fatigue, pharyngitis, lymphadenopathy, anorexia, arthralgia, myalgia, rash, and headache. Some patients seek no medical attention for such symptoms, and others recall no symptoms whatsoever. Physicians in all...

INTRODUCTION We present an interesting case of Candida lusitaniae infection in a patient diagnosed with renal clear cell carcinoma.An 82-year-old male presented with worsening back pain for 1 week. Physical examination including neurologic examination was normal. A computed tomography scan of the abdomen revealed a mass in the right upper pole of the kidney suggestive of a renal neoplasm. Patho...

Abstract Six-monthly blood monitoring is performed for patients with psoriasis-prescribed biological drugs at most UK centres. This has significant healthcare cost implications, creates a burden on patient time and considerable environmental impact. We aimed to investigate abnormalities in prescribed biologics our centre, determine whether the frequency could be reduced. reviewed records of pso...

PURPOSE BMS-214662 is a nonsedating benzodiazepine derivative that exhibits broad spectrum cytotoxicity against human solid tumor cell lines and potently inhibits farnesylation of the H-ras and K-ras oncogenic proteins. This report describes the initial Phase I clinical trial of the compound. The main objective of the study was to determine the dose-limiting toxicities and the maximum tolerated...

A 28-year-old nonobese woman, with a history of hyper-tension, presented with fatigue and generalized weakness of 4-year duration. The physical examination was remarkable for bilateral pseudophakia, hypertension, and a basal systolic murmur radiating to the right axilla and back. All peripheral pulses were symmetrical, and there were no bruit, either over the renal artery or elsewhere. Fundusco...