Background & Aims Mutations in the APC gene and other genes Wnt signaling pathway contribute to development of colorectal carcinomas. R-spondins (RSPOs) are secreted proteins that amplify intestinal stem cells. Alterations RSPO have been identified human tumors. We studied effects RSPO1 overexpression ApcMin/+ mutant mice. Methods An adeno associated viral vector encoding RSPO1-Fc fusion protei...

Mevalonate pyrophosphate decarboxylase is a kind of key enzyme in the terpenoid synthesis pathway Eleutherococcus senticosus. The results bisulfite sequencing showed that there were three kinds samples with low (0.68%), medium (0.72%) and high (0.79%) DNA methylation ratio promoter MDD E. senticosus, respectively. transcriptome expression senticosus was significantly up-regulated types ratios (...

Regulation of synaptic AMPA receptor levels is a major mechanism underlying homeostatic synaptic scaling. While in vitro studies have implicated several molecules in synaptic scaling, the in vivo mechanisms linking chronic changes in synaptic activity to alterations in AMPA receptor expression are not well understood. Here we use a genetic approach in C. elegans to dissect a negative feedback p...

The PI3K pathway is one of the most highly perturbed cell signaling pathways in human cancer, including the most common malignant brain tumors, gliomas, where either activating mutations of positive pathway effectors or loss/inactivation of pathway inhibitors occurs. Knowledge of the precise transcription factors modulated by PI3K in tumor cells remains elusive but there are numerous PI3K-respo...

background: the aim of the current study was to assess the mrna levels of two mitochondria-related genes, including nuclear-encoded nrf1 (nuclear respiratory factor 1), mitochondrial transcription factor a (tfam), and mitochondrial-encoded cytochrome c oxidase subunit 1 (mt-co1) genes in various stages of the human oocyte maturation. methods: oocytes were obtained from nine infertile women with...

the characteristics of cellular and molecular mechanisms associated with cell proliferation and differentiation is important to understand malignancy. in this report we characterise a leukemic model, d5a1, to study the action of differentiation agent, cellular events and gene expression of the selected transcription factors. cells induced with 4 mm hexamethylene bisacetamide (hmba) caused signs...

YAP (Yes-associated protein) and its paralog TAZ (transcriptional co-activator with PDZ-binding motif) are the main downstream effectors of the Hippo signaling pathway. This pathway is an evolutionally conserved signal cascade, which plays pivotal roles in organ size control and tumorigenesis from Drosophila to mammals. Functionally, when the Hippo pathway is activated, YAP and TAZ will be sequ...

Nuclear factor of activated T cells (NFAT) is a family of transcription factors important for innate and adaptive immune responses. NFAT activation is tightly regulated through the calcineurin/NFAT signaling pathway. There is increasing evidence on non-coding RNAs such as miRNAs playing a crucial role in regulating transcription factors and signaling pathways. However, not much is known about m...

lymphomas are solid tumors of immune system and non-hodgkin lymphomas (nhl) is the most prevalent lymphomas; with wide ranges of histological and clinical features, it is so difficult to identify them. herein, various bioinformatics tools (such as gene differential expressions, epigenetics and protein analysis) employed to find new treatment approach for nhl based on gene expression variation b...

Exploration of the abnormal expression exosomal molecules during infection avian leukosis virus subgroup J (ALV-J) is essential to provide a deeper understanding exosome’s role in viral pathogenesis involved. The study aimed investigate differentially expressed proteins and miRNAs exosomes derived from DF-1 cells infected by ALV-J, their gene function involved signal pathways. We isolated ALV-J...