There is now scientific evidence of genetically driven skin-barrier anomalies in atopic patients. These barrier anomalies facilitate sustained antigen ingress through the defective barrier, which can bring about a Th2-dominant response. It enhances the transepidermal water loss, resulting in dry skin and leading to the release of preformed proinflammatory cytokines and to a cascade of events en...

Abbreviations: TEWL: Transepidermal Water Loss; AD: Atopic Dermatitis; SC: Stratum Corneum; HC: Healthy Control; PiCl: Picryl Chloride; MA: House Dust Mite Antigens; SM: Sphingomyelin; GCer: Glucosylceramide; BGCase: Beta-Glucocerebrosidase; SMase: Acid Sphingomyelinase; CBE: Conduritol B Epoxide; DSP: Despiramine Hydrochloride; PDMP: 1-Phenyl-2-Decanoylamino-3-Morpholino-1Propanol; SPT: Serine...

The fetus is supplied from the placenta with estradiol (E2) and progesterone (P) in increasing amounts during gestation. After delivery of a premature infant, placental supply is disrupted, resulting in a rapid decrease in E2 and P. Replacement of these placental hormones may restore intrauterine conditions and may be beneficial for bone mineral accretion, clinical course, and outcome. Thirty f...

PURPOSE To study the effects of varying lipid concentrations, lipid and oil ratio, and the addition of propylene glycol and lecithin on the long-term physical stability of nanostructured lipid nanocarriers (NLC), skin hydration, and transepidermal water loss. METHODS The various NLC formulations (A1-A5) were prepared and their particle size, zeta potential, viscosity, and stability were analy...

This study was designed to formulate, pharmaceutically evaluate a topical skin-care cream (w/o emulsion) of Aloe Vera versus its vehicle (Base) as control and determine their effects on Stratum Corneum (SC) water content and Transepidermal water loss (TEWL). Base containing no extract and a Formulation containing 3% concentrated extract of Aloe Vera was developed by entrapping in the inner aque...

propene dissociation channels were characterized by ab initio ccsd(t)/6-311++g(d,p) calculations. inthis work the detailed mechanism of propene dissociation to c2h4+ch2, c2h2+h+ch3, c2h2+ch4 andc3h3+h2+h have been investigated. according to our calculations, ten fragments can be classified intofive dissociated channels. our results point out that two mechanisms come into play in the h2 eliminat...